mTOR Antibody (NBP1-19934)
mTOR [p Ser2448] Antibody
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Distributor Data...
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anti-Raptor antibody, anti-RAPTOR antibody, anti-P150 target of rapamycin (TOR)-scaffold protein antibody, anti-KIAA1303 antibody, |
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mTOR [p Ser2448] Antibody Summary: | | Gene: | MTOR |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional mTOR Products mTOR [p Ser2448] Antibody Details: | Immunogen: | Synthetic peptide corresponing to the residues surrounding Serine 2448 of human p-mTOR |
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| Modification: | p Ser2448 |
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| Uses: | This antibody is useful for Immunohistochemistry. Immunohistochemistry analyzes of p-mTOR (S2448) antibody in paraffin-embedded human brain tissue. |
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| Dilutions: | Immunohistochemistry-Paraffin 1:50-1:200 |
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| Unit Size: | 0.1 mg |
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| Concentration: | 1.0 mg/ml |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Phosphate buffered saline (PBS), approx. pH 7.2. |
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| Preservative: | 15mM Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
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Images (1) Reviews (0) Related Products (45) Exploring mTOR
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Working with mTOR
mTOR [p Ser2448] Antibody Images (1) Immunohistochemistry: mTOR phosphospecific Antibody [NBP1-19934] - mTOR phosphospecific Antibody [NBP1-19934] - paraffin-embedded human brain tissue. |
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Jump to: Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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