mTOR Antibody (NB100-82052)
mTOR [p Ser2448] Antibody
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anti-FK506 binding protein 12 rapamycin complex associated protein 1 antibody, anti-RAPT1 antibody, anti-Rapamycin target protein antibody, anti-RAFT1 antibody, anti-mammalian target of rapamycin antibody, anti-FRAP2 antibody, anti-FRAP1 antibody, anti-FRAP antibody, anti-FKBP12 rapamycin complex associated protein antibody, anti-FK506 binding protein12-rapamycin associated protein 2 antibody, anti-FK506 binding protein12-rapamycin associated protein 1 antibody, |
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mTOR [p Ser2448] Antibody Summary: | | Gene: | MTOR |
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| Purity: | Immunogen affinity purified |
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| Host: | Rabbit |
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| | Specificity: | mTOR (specific to Phospho-Ser2448) detects endogenous levels of mTOR only when phosphorylated at serine 2448. |
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| Publications: | Antibody has at least 4 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional mTOR Products mTOR [p Ser2448] Antibody Details: | Isotype: | IgG |
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| Immunogen: | The antiserum was produced against synthesized phosphopeptide derived from human mTOR around the phosphorylation site of serine 2448 (T-D-SP-Y-S). |
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| Modification: | p Ser2448 |
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This antibody is reactive against Human, Mouse, Rat |
| Uses: | This antibody is useful for:
immunohistochemistry-Paraffin 1:50-1:100 |
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| Dilutions: | Immunohistochemistry-Paraffin |
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| Unit Size: | 0.05 mg |
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| Concentration: | 1.0 mg/ml |
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| Positive Controls: | 1 Positive Controls |
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Packaging: | Storage: | Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles. |
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| Buffer: | phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol. |
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| Preservative: | 0.02% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kD protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
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Images (1) Reviews (0) Related Products (45) Exploring mTOR Working with mTOR
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Jump to: Publications, Images, Ask a Question
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Working with mTOR
mTOR [p Ser2448] Antibody Images (1) Immunohistochemistry: mTOR Phosphospecific Antibody [NB100-82052] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using mTOR (phospho-Ser2448) antibody |
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Publications (4)mTOR [p Ser2448] Antibody Background References:- Bolster DR, et,al. (2003) J Physiol ;553:213-220.
- Mothe-Satney I, et,al. (2004) J Biol Chem ;279: 42628-42637
more... - Chiang GG, et,al. (2005) J Biol Chem ;280: 25485-25490
- Holz MK, et,al. (2005) J Biol Chem ;280:26089-26093
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Jump to: Positive Controls, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsPositive ControlsLysates (1)Peptides and ProteinsPrimary Antibodies (41)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| mTOR Antibody (EP4120) | NBP1-96084 | Hu, Mu, Rt | ICC, IF, IHC-P, WB | (3) | | | | | mTOR Antibody (Y391) | NB110-56996 | Hu, Mu, Rt | FACS, ICC, IHC-P, IP, WB | (2) | (1) | | | | mTOR [p Ser2448] Antibody | NB600-607 | Hu | ELISA, IHC, IHC-P, WB | (2) | (1) | | | | mtor Antibody (EPR426(2)) | NBP1-96067 | Hu | ICC, IF, IHC-P, WB | (3) | | | | | mTOR Antibody | NBP1-02454 | Ca, Hu, Mu, Rt, Ze | ELISA, IF, IHC-P, WB | (2) | | | | | ... and 36 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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