mTOR Antibody

Species: Mu, Hu Applications: WB Clonality: Polyclonal	Gene: MTOR Purity: Peptide affinity purified Host: Rabbit
Specificity: mTOR
See All mTOR Products See All mTOR Related Products: Antibody Packs Lysates Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Immunogen:	Synthetic peptide derived from the sequence of human mTOR

Entrez:	2475 (Human)
	56717 (Mouse)
Related Genes:	AKT1, EIF4EBP1, RPS6KB1, PSMC4, PIK3R1, PIK3CB, PIK3CG, INS, TSC2, EIF4E, UBASH3B, ANXA6, ELF1, MAPK1, TSC1, PTEN, MAPK3, VEGFA, RPS6, EGFR, EPHB2, CRTC2, KRAS, PRKAA2, PRKAB1, RPTOR, RHEB, IRS1, HRAS1, CCND1, MDK, EIF4G1, CDKN1A, HIF1A, TNF, TRP53, TP53, RORC, EEF2, RICTOR

Mammalian target of rapamycin (mTOR) is an atypical serine-threonine protein kinase and member of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. TORC1 (mTOR, GbetaL/mLST8 and Raptor) and TORC2 (mTOR, GbetaL/mLST8, SIN1, and Rictor) complexes control protein synthesis through the direct or indirect phosphorylation of downstream targets such as S6 Kinase and 4EBP1, key regulators of mRNA recruitment to ribosomes. Through its involvement in several key signaling pathways and its critical role in transcription and translation, mTOR mediates cell proliferation, differentiation, and survival. Recent studies identified the TORC2 complex as the missing kinase activator of Akt/PKB, deregulation of which has been implicated in the pathogenesis of cancer and diabetes.

Reactivity:	Human, Mouse.

Uses:	This antibody is useful for Western blot.
Dilutions:	Western Blot,

Storage:	Store at -20C. Avoid freeze-thaw cycles.
Preservative:	Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.