Factor I is a plasma protein of molecular weight 88 kDa, consisting of two disulphide linked chains of 50 and 38 kDa. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It has a requirement for protein cofactors for cleavage of these complement proteins, Factor H, CR1 or MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.
AHUS3 , C3b-inactivator , C3B/C4B inactivator , C3BINA , complement component I , complement control protein factor I , complement factor I heavy chain , complement factor I , EC 3.4.21 , EC 3.4.21.45 , FIC3b-INA , I factor (complement) , IF , KAF , Konglutinogen-activating factor , light chain of factor I