Acrp30 antibody

Mouse Monoclonal anti-Acrp30 (Ne.Na)

Catalog Number: NB120-16086	Price: $285.00

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Background:

Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis.

Alternate Names:

anti-30 kDa adipocyte complement related protein antibody, anti-ACDC antibody, anti-ACRP 30 antibody, anti-ACRP30 antibody, anti-Adipocyte C1q and collagen domain containing protein antibody, anti-Adipocyte complement related 30 kDa protein antibody, anti-Adipocyte complement related protein of 30 kDa antibody, anti-AdipoQ antibody, anti-Adipose most abundant gene transcript 1 antibody, anti-APM 1 antibody, anti-ApM1 antibody, anti-GBP 28 antibody, anti-GBP28 antibody, anti-Gelatin binding protein antibody

Related Diseases:

Atherosclerosis, Coronary Artery Disease, Insulin Resistance, Obesity

Host:

Mouse

Research Areas:

Lipid and Cardiovascular Research

Immunogen:

Recombinant human ACRP30 headless (tail adiponectin) protein.

Clone:

Ne.Na

Isotype:

IgG1

Localization:

Secreted

Species Reactivity:

Cross-reacts with Human.Does not cross-react with Mouse.Not yet tested in other species.
Other species have not been tested.

Uses:

ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 ug/ml. Predicted molecular weight: 29 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
ELISA, immunoprecipitation, Western Blot
* Investigator should determine optimal working dilutions.

Packaging:

0.05 mg Affinity purified Mouse IgG.

Concentration:

1 mg/ml

Buffer:

PBS

Preservative:

0.02% Sodium Azide

Storage:

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

Gene Id:

9370

Gene System:

ADIPOQ

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