ACCN1 antibody

Rabbit Polyclonal anti-ACCN1

Catalog Number: NB110-74733	Price: $295.00

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Background:

FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.; SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM. Interacts with PRKCABP and ACCN3.; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.

Alternate Names:

anti-Amiloride-sensitive brain sodium channel antibody, anti-acid-sensing ion channel 2 antibody, anti-ASIC2 antibody, anti-brain sodium channel 1 antibody, anti-BNaC1 antibody. anti-BNC1 antibody, anti-mammalian degenerin homolog antibody, anti-ACCN antibody, anti-BNAC1 antibody, anti-MDEG antibody

Host:

Rabbit

Immunogen:

A synthetic peptide as a part of human & monkey (macaca fascicularis) amiloride-sensitive cation channel 1 (ASIC1) conjugated to immunogenic carrier protein was used as the immunogen.

Specificity:

Appears to be specific for ASIC2.

Localization:

Cell Membrane; multi-pass membrane protein

Species Reactivity:

Human. Other species not yet tested.
Other species have not been tested.

Uses:

IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
immunohistochemistry
Western Blot 1:300
* Investigator should determine optimal working dilutions.

Packaging:

0.1 ml of Whole antisera antibody

Buffer:

Lyophilised in PBS

Preservative:

No Preservative

Storage:

Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

General References:

1. Price M.P, et al. J. Biol. Chem. 271:7879-7882(1996).
2. Waldmann R, et al. J. Biol. Chem. 271:10433-10436(1996).
3. Garcia-Anoveros J, et al. Proc. Natl. Acad. Sci. U.S.A. 94:1459-1464(1997).
4. Babinski K, et al. J. Biol. Chem. 275:28519-28525(2000).
5. Hruska-Hageman A.M, et al. Biochem. J. 361:443-450(2002).

Notes:

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Gene Id:

40

Gene System:

ACCN1

Omim ID:

ASIC1_HUMAN ; ASIC1_MONKEY

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