ACVR1 antibody

Goat Polyclonal anti-ACVR1

Catalog Number: NB100-79865	Price: $295.00

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Background:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Alternate Names:

anti-CVR1 antibody, anti-activin A receptor antibody, anti-type I antibody, anti-ACTRI antibody, anti-ACVRLK2 antibody, anti-ALK2 antibody, anti-FOP antibody, anti-SKR1 antibody, anti-activin A receptor antibody, anti-type II-like kinase 2 antibody, anti-activin A type I receptor antibody, anti-hydroxyalkyl-protein kinase antibody

Host:

Goat

Immunogen:

Synthetic peptide, C-RKFKRRNQERLNPRD, representing the internal region of the sequence according to NP_001096.1

Isotype:

IgG

Epitope:

RKFKRRNQERLNPRD

Reference Sequence:

NP_001096.1

Species Reactivity:

Human.
Other species have not been tested.

Homology:

Human, Mouse, Rat, Dog

Uses:

Peptide ELISA: antibody detection limit dilution 1:128,000. Western Blot: Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Recommended concentration: 0.3-1ug/ml.
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
ELISA 1:128000
Western Blot 0.3-1ug/ml
* Investigator should determine optimal working dilutions.

Packaging:

0.1 mg Immunogen affinity purified Goat antisera.

Concentration:

0.5 mg/ml

Buffer:

Tris-saline [pH7.3] with 0.5% BSA

Preservative:

0.02% Sodium Azide

Storage:

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

General References:

Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. 2006 May;38(5):525-7. Epub 2006 Apr 23. Erratum in: Nat Genet. 2007 Feb;39(2):276. FOP International Research Consortium

Gene Id:

90

Gene System:

ACVR1

NB100-79865 (0.3?g/ml) staining of Human Umbilical Cord lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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