ACE2 antibody

Rabbit Polyclonal anti-ACE2

Catalog Number: NB100-55874	Price: $335.00

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Background:

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Host:

Rabbit

Immunogen:

Human ACE2 (NT) peptide.

Isotype:

IgG

Species Reactivity:

Human Not yet tested in other species.
Other species have not been tested.

Uses:

WB: 0.5-2 ug/ml ~; IHC (paraffin): 2 ug/ml
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
immunohistochemistry,
Western Blot
* Investigator should determine optimal working dilutions.

Positive Controls:

Human kidney or human testis cell lysate can be used as positive control.
* Human Kidney Protein NB820-59231
* Human Testis Protein NB820-59266

Packaging:

0.05 mg Rabbit antisera.

Buffer:

PBS containing 0.02% sodium azide.

Storage:

Store at 4C. Do not freeze.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

Gene Id:

59272

Gene System:

ACE2

Western blot analysis of ACE2 in human kidney lysate with anti-ACE2 (NT) using NB100-55874 at 1 ug/ml. Immunohistochemical staining of human kidney cells using anti-ACE2 (NT) at 2 ug/ml.

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