ACVRL1 antibody

Goat Polyclonal anti-ACVRL1

Catalog Number: NB100-1396	Price: $195.00

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Background:

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application.

Activin A receptor, type II-like 1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2; MIM 600376 ) also known as Rendu-Osler-Weber syndrome 2 (ORW2).Note: ACVRL1 is also known as ALK1 - not to be confused with the similarly named ALK (anaplastic lymphoma kinase).

Alternate Names:

anti-Activin A receptor antibody, anti-activin A receptor type II-like 1 antibody, anti-activin receptor-like kinase 1 antibody, anti-ACVRLK1 antibody, anti-ALK1 antibody, anti-HHT antibody, anti-HHT2 antibody, anti-ORW2 antibody, anti-SKR3 antibody, anti-type II-like kinase 1 antibody

Host:

Goat

Research Areas:

Nuclear Receptors, Coactivators and Corepressors, Cell Biology, Growth and Development

Immunogen:

Synthetic peptide: KISNSPEKPKVIQ representing the C-Terminus of the human protein (residues 491-503) according to NP_000011.

Isotype:

IgG

Species Reactivity:

Cross-reacts with Human. Not yet tested in other species.
Other species have not been tested.

Uses:

This antibody can be used for ELISA and Western Blot. In Western Blot, preliminary experiments gave no signal but low background in human lung and liver extracts. Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Other applications have not been tested.

Dilutions:

Suggested working dilutions *
ELISA >1:32,000,
Western Blot 1µg/ml
* Investigator should determine optimal working dilutions.

Positive Controls:

Lung and liver extracts.

Packaging:

0.1 mg Immunogen affinity purified Goat antisera.

Concentration:

0.5 mg/ml

Buffer:

Tris saline containing [pH7.3] with 0.5% BSA

Preservative:

0.02% Na azide

Storage:

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Limitations:

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 6 months from date of receipt.

General References:

Johnson DW et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet 13:189-95 (1996).

Notes:

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application.

Gene Id:

94

Gene System:

ACVRL1

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