ABCG8 Antibody
Rabbit Polyclonal anti-ABCG8, Sample Size
Price: $100.00
  • Catalog Number: NB400-110SS
  • Unit Size: 0.025 ml
Product Images
Western blot analysis of ABCG8, using NB 400-110. Samples: mouse liver microsomes from G5/G8 knockout mice, wildtype human G5/G8, and transgenic human G5/G8. 
Gene ID 64241 Reference Sequence Q9H221 
Species Summary Hu(+) Mu(-)  Application Summary WB 
Purity Immunogen affinity purified Host Rabbit 
Storage

Store at 4C. Do not freeze.
Background

ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
Research Areas

Lipid and Metabolism,     ABC Transporters,     Cholesterol Metabolism,    

Related Diseases

Atherosclerosis, Coronary Artery Disease
Immunogen

A synthetic peptide from the N-terminal region of human ABCG8 protein.
Specificity

Specific for ABCG8.

Localization

Integral membrane protein; multi-pass membrane protein.
Species Reactivity

Human. Does not appear to cross react with mouse.
Uses

This antibody is useful for Western Blot .
Dilutions

Western Blot 1:500

Concentration

1 mg/ml
Packaging

0.025 ml Immunogen affinity purified Rabbit antisera.
Preservative

0.1% sodium azide
Alternate Names

anti-ATP binding cassette sub family G (WHITE) member 8 (sterolin 2) antibody, anti-ATP binding cassette sub family G member 8 antibody, anti-MGC142217 antibody, anti-Sterolin 2 antibody, anti-STSL antibody, anti-ATP binding cassette G8 antibody
Gene Symbol

ABCG8
 
 
 

1. Kobayashi, A., et al. Efflux of sphingomyelin cholesterol and phosphatidylcholine by ABCG1. J. Lipid Res. 47:1791-1802, 2006.

2. 2. Mathur, S. N., Watt, K. R., and Field, F. J. (2007) Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid, J. Lipid Res. 48: 395-404.