Bookmark / Share / Email / Print
- Catalog Number: NB120-16086
- Unit Size: 0.05 mg
| Gene ID | 9370 | Reference Sequence | |
| Species Summary | Hu(+) Mu(-) | Application Summary | ELISA, IP, WB |
| Purity | Affinity purified | Host | Mouse |
| Clone | Ne.Na |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Background | Adipose cells produce and secrete numerous physiologically important proteins, such as Lipoprotein Lipase, Leptin, and Adipocyte Complement Related protein of 30 kDa, also known as Acrp30 or Adiponectin. Adiponectin is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, Adiponectin mRNA is induced >100 fold. Adiponectin improves the ability of insulin to suppress glucose production, at sub physiological levels, thereby linking adipose tissue to whole body glucose regulation. Adiponectin function appears to be regulated by phosphatidylinositol 3 kinase (PI3K) since Adiponectin secretion is blocked by pharmacologic inhibitors of this kinase. Adiponectin mRNA is significantly reduced in adipose tissue of obese patients with Type 2 diabetes. The structural similarity of Adiponectin to TNF alpha suggests that Adiponectin may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Adiponectin is implicated as a regulator of whole body energy homeostasis. |
| Research Areas | |
| Related Diseases | Atherosclerosis, Coronary Artery Disease, Insulin Resistance, Obesity |
| Isotype | IgG1 |
| Immunogen | Recombinant human ACRP30 headless (tail adiponectin) protein. |
| Localization | Secreted |
| Species Reactivity | Cross-reacts with Human.Does not cross-react with Mouse.Not yet tested in other species. |
| Uses | ELISA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at a concentration of 1 ug/ml. Predicted molecular weight: 29 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Dilutions |
ELISA, immunoprecipitation, Western Blot |
| Concentration | 1 mg/ml |
| Positive Controls: | * Antigen standard for ADIPOQ (NM_004797) (transient overexpression lysate) |
| Packaging | 0.05 mg Affinity purified Mouse IgG. |
| Buffer | PBS |
| Preservative | 0.02% Sodium Azide |
| Clonality | Monoclonal |
| Alternate Names | anti-30 kDa adipocyte complement related protein antibody, anti-ACDC antibody, anti-ACRP 30 antibody, anti-ACRP30 antibody, anti-Adipocyte C1q and collagen domain containing protein antibody, anti-Adipocyte complement related 30 kDa protein antibody, anti-Adipocyte complement related protein of 30 kDa antibody, anti-AdipoQ antibody, anti-Adipose most abundant gene transcript 1 antibody, anti-APM 1 antibody, anti-ApM1 antibody, anti-GBP 28 antibody, anti-GBP28 antibody, anti-Gelatin binding protein antibody |
| Gene Symbol | ADIPOQ |
|
|