ACVR1 Antibody
Goat Polyclonal anti-ACVR1
Price: $295.00
  • Catalog Number: NB100-79865
  • Unit Size: 0.1 mg
Product Images
NB100-79865 (0.3?g/ml) staining of Human Umbilical Cord lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 
Gene ID 90 Reference Sequence NP_001096.1 
Species Summary Ca(+) Hu(+) Mu(+) Rt(+)  Application Summary ELISA, WB 
Purity Immunogen affinity purified Host Goat 
Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Isotype

IgG
Immunogen

Synthetic peptide, C-RKFKRRNQERLNPRD, representing the internal region of the sequence according to NP_001096.1
Epitope

RKFKRRNQERLNPRD
Species Reactivity

Human. Expected from sequence similarity: mouse, canine and rat
Uses

Peptide ELISA and Western Blot: Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1).

Dilutions

ELISA 1:128000, Western Blot 0.3-1ug/ml
Concentration

0.5 mg/ml
Packaging

0.1 mg Immunogen affinity purified Goat antisera.
Buffer

Tris-saline [pH7.3] with 0.5% BSA
Preservative

0.02% Sodium Azide
Alternate Names

anti-CVR1 antibody, anti-activin A receptor antibody, anti-type I antibody, anti-ACTRI antibody, anti-ACVRLK2 antibody, anti-ALK2 antibody, anti-FOP antibody, anti-SKR1 antibody, anti-activin A receptor antibody, anti-type II-like kinase 2 antibody, anti-activin A type I receptor antibody, anti-hydroxyalkyl-protein kinase antibody
Gene Symbol

ACVR1
 
 
 

Shore EM, Xu M, Feldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers JG, Smith R, Triffitt JT, Urtizberea JA, Zasloff M, Brown MA, Kaplan FS. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet. 2006 May;38(5):525-7. Epub 2006 Apr 23. Erratum in: Nat Genet. 2007 Feb;39(2):276. FOP International Research Consortium