Support: 303-730-1950
flag Worldwide (Choose your country.)
 

BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might be a tumor suppressor gene. BRCA 2 confers only a low ovarian cancer risk. Reportedly, in MCF-10F (normal breast epithelial cell line) and MCF-7 (breast cancer cell line) cells the expression of BRCA 2 RNA lowers in G0 and early G1 phases then gets up-regulated at the G1 / S phase junction.

Gene ID: 675
(see alternate names)
BRCA1/BRCA2-containing complex, subunit 2 , BRCC2 , breast and ovarian cancer susceptibility gene, ear, breast cancer 2 tumor suppressor , breast cancer 2, early onset , breast cancer susceptibility protein BRCA2 , breast cancer type 2 susceptibility protein , BROVCA2 , FACD , FAD , FAD1 , FANCB , FANCD , FANCD1Fanconi anemia, complementation group D1 sli, Fanconi anemia group D1 protein , GLM3 , PNCA2

Breast Cancer and RAD51L1 Antibodies

In the United States, breast cancer is one of the most common cancers and the second leading cause of cancer related deaths in women. According to the American Cancer Society's most recent estimates ...
[Read More]

Determining DMC1's role in Homologus Recombination

The DMC1 gene encodes a 36.7 kDa nuclear protein involved in meiotic homologous recombination. This recombinase is functionally related to the yeast RAD51 ...
[Read More]

Rad51 Antibody Reveals a Canine Model for Human Breast Cancer

Our antibody catalog includes an extensive range of Rad51 antibody reagents. Encoded by the RAD51 gene, the Rad51 protein plays a vital role in DNA repair, interacting with several other ...
[Read More]