The BRCA1 gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. BRCA1 is expressed in the cells of breast and other tissue, where it helps to repair double strand DNA breaks and initiate apoptosis in cells with excessive damage. BRCA1 mutations lead to improper DNA repair and eventually to cancer development.
BRCA1 antibodies are useful for cancer studies.
BRCAI , breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset , breast cancer type 1 susceptibility protein , EC 6.3.2 , EC 6.3.2.- , IRIS , PNCA4 , PSCP , subunit 1