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The BRCA1 gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. BRCA1 is expressed in the cells of breast and other tissue, where it helps to repair double strand DNA breaks and initiate apoptosis in cells with excessive damage. BRCA1 mutations lead to improper DNA repair and eventually to cancer development.

BRCA1 antibodies are useful for cancer studies.

Gene ID: 672
BRCAI , breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset , breast cancer type 1 susceptibility protein , EC 6.3.2 , EC 6.3.2.- , IRIS , PNCA4 , PSCP , subunit 1

NUP153 & 53BP1: A Novel DNA Repair Pathway

Mediating DNA damage is a crucial process, and one of the most important cellular guards against cancer. In response to DNA damage, sophisticated cellular machinery is recruited to repair the breaks, and if it fails, the cell is committed to death. ...
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Breast Cancer and RAD51L1 Antibodies

In the United States, breast cancer is one of the most common cancers and the second leading cause of cancer related deaths in women. According to the American Cancer Society's most recent estimates ...
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BRCA1: Breast Cancer and Beyond

BRCA1, also known as breast cancer type 1 susceptibility protein and RING finger protein 53, belongs to a class of genes known as tumor suppressors. BRCA1 regulates cell growth and division, ...
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