ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
a1 , ATP6N1 , ATP6N1AATPase, H+ transporting, lysosomal non-cata, ATPase, H+ transporting, lysosomal (vacuolar proto, ATPase, H+ transporting, lysosomal V0 subunit a is, ATPase, H+ transporting, lysosomal V0 subunit a1 s, Clathrin-coated vesicle/synaptic vesicle proton pu, DKFZp781J1951 , Stv1 , V-ATPase 116 kDa isoform a1 , V-ATPase 116 kDa , V-type proton ATPase 116 kDa subunit a isoform 1 s, V-type proton ATPase 116 kDa subunit a , Vacuolar adenosine triphosphatase subunit Ac116 sl, Vacuolar proton pump subunit 1 , vacuolar proton pump, subunit 1 , vacuolar proton translocating ATPase 116 kDa subun, Vacuolar proton translocating ATPase 116 kDa subun, vacuolar-type H(+)-ATPase 115 kDa subunit , Vph1 , VPP1H(+)-transporting two-sector ATPase, 116 kDa a
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