There are three human isoforms of the AKT gene, which plays a key role in several signalling pathways. Akt antibody studies have shown the Atk kinases to play a diverse number of roles within the cell, regulating angiogenesis, apoptosis, protein synthesis, intermediary metabolism and cellular differentiation. We at Novus Biologicals have a wide range of Akt products on our antibody database, targeting all three isoforms.
Akt antibody research has identified specific roles for the three isoforms of Akt. Akt1, the founding member of the family, is of major importance to cancer researchers. A key player in the PI3K/AKT/mTOR and several other pathways, Akt1 signalling promotes hypertrophy (growth) of skeletal muscle and other tissues, and promotes cell survival by inhibiting apoptotic processes. Akt2 plays an important role in insulin signalling, while Akt3 is thought to be involved with neuronal development.
Akt1 was originally identified as an oncogene in the AKT8 transforming retrovirus, and has since been shown to be critical to the growth and progression of a number of human neoplasms. It also plays an indirect role, acting on oncogenic signals resulting from mutations in tumor-suppressor genes and other oncogenes.Today, the entire Akt antibody database is used in cancer research. Overexpression of Akt2 and Akt3 has been directly linked to the development of epithelial neoplasms, breast tumors, prostate cancer, ovarian cancer and skin cell melanomas. Researchers at the MORI Institute, Tufts University, are using insertional mutagenesis and other genetic techniques to probe the function of all three isoforms. Other groups are using Akt antibody products to develop antineoplastic drugs.
Novus Biologicals offers many AKT reagents for your research needs including: