Neuroscience eNews - 1st Edition

Conferences and Events
39th annual meeting of the Society for Neuroscience will be held October 17th through October 21st 2009.  Stop by and visit the Novus representatives at Booth 1719. Bring a copy of this e-mail to redeem your complimentary gift! 

Featured Neuroscience Antibodies: Parkinson’s Disease Targets
Approximately one million Americans suffer from Parkinson’s Disease, with 60,000 new cases expected to be diagnosed currently each year. Parkinson’s Disease belongs to a group of progressive neurodegenerative diseases know as synucleinopathies characterized by  the presence of abnormal α-synuclein-immunoreactive inclusions within neurons.

NBP1-26380 Mouse Monoclonal anti-Nitrated alpha-Synuclein Antibody

Nitrated alpha-Synuclein is a soluble protein primarily localized at the presynaptic regions of axons. It can form filamentous aggregates, which are the major non- amyloid component of intracellular inclusions in many neurodegenerative synucleinopathies. Nitrated alpha-Synuclein has been found to reduce neuronal responsiveness to several apoptotic stimuli which leads to a decreased caspase-3 activation.

NB300-268 Rabbit Polyclonal anti-LRRK2 Antibody

Leucine-rich repeat kinase 2 (LRRK2) is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson's Disease 8 (PARK8). PARK8 is an autosomal-dominant late-onset parkinsonism with slow progression.

NB100-483 Rabbit Polyclonal anti- PARK7 Antibody

Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal-recessive, early-onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Mutations in the PARK7/DJ-1 gene cause autosomal-recessive Parkinson's Disease.

Coming Soon: Customer Reviews Published on our Website

Neurofilaments heavy (NF-01) Antibody [NB500-416]

This antibody was given 5 out of 5 stars in a customer review submitted April 20, 2009. The customer stated it was a “excellent product.” The customer this antibody in immunohistochemistry on mouse spinal nerves.

  -Anonymous Reviewer

NMDA Receptor 1 Antibody [NB100-74473]

This antibody was given 5 out of 5 stars in a customer review submitted July 29, 2009.The customer stated “This antibody is very effective for staining NR1 receptors in the brain, better than the 3 other ones I have tried in the past.  1:2000 works equally well as 1:200.”

  -Review submitted by Dr. Rick Shin (Rick.Shin@us.astellas.com)

Conjugated Primary Antibodies
Many of Novus’ most popular antibodies are now available directly conjugated.  Antibodies are available conjugated to Dylight 488, 549 and 649, as well as Biotin and HRP.

New Product Information
•25% OFF select Neuroscience-related antibodies and proteins. View the list here.

Novus Neuroscience Antibodies In The News
[IRE1 Alpha NB100-2323] Hoozemans JJ, van Haastert ES, Nijholt DA, et al. The unfolded protein response is activated in pretangle neurons in Alzheimer's Disease hippocampus. Am J Pathol. 2009 Mar 5. [PMID 19264902]

[MFN1 Antibody NB110-58853]  Wang X, Su B, Lee H-g, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's Disease. J Neurosci 2009;29(28):9090-9103. [PMID: 19605646]

[Pink1 NB100-493]  Lutz AK, Exner N, Fett ME, et al. Loss of Parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem. 2009;284(34):22938-22951. [PMID: 19546216]

[Vimentin Antibody NB300-223]  Ponzo MG, Lesurf R, Petkiewicz S, et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. PNAS 2009;106(31):12903-12908. [PMID: 19617568]