Lipid & Metabolism eNews - 1st Edition

Spotlight on SCD1
SCD1 controls glucose-mediated lipogenesis by modulating the rate of synthesis of fatty acids.  The conversion of glucose into lipogenic substrates is a critical metabolic event in cancer cells.  The inactivation of SCD1 reduces cancer cell proliferation and in vitro invasiveness and impairs tumor formation and growth (JBC 280: 25339-25349, 2005).   

NBP1-26393
Western blot of SCD1 on normal human live using NBP1-26393.

New Products
SREBP1
SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in apoptotic processes. More

PGC1 alpha • NBP1-04676	ACSL • NB110-99585	GSK3 beta • NBP1-02156
Western blot of PGC1 alpha on human liver using NBP1-04676.	Western blot of ACSL on HepG2 whole cell lysates using NB110-99585.	Western blot of GSK3B in A431 whole cell lysates using NBP1-02156.

PDK4 • NBP1-07047	GLO1 • NBP1-19015	Adropin • NBP1-26387
Western blot on human heart protein lysate using NBP1-07047 .	Immunostaining of human retinal endothelial cells using NBP1-19015.	Western blot of Adropin on mouse brain lysate using NBP1-26387.

Coming Soon: Customer Reviews Published on our Website

LDL Receptor Antibody [NB110-57162]

This antibody was given five stars in a customer review submitted July 30, 2009.  The customer said “so far [this is] the best antibody for LDL receptor.  I did try a bunch of them (from Abcam for example without success).”  The customer tested this LDL Receptor antibody in Hep2 and HepG2 cell lines at a 1:500 dilution, using liver extract as a positive control, and achieved a specific band at 150 kDa.

New Product Information
•25% OFF select lipid-related antibodies and proteins. View the list here.

New Publications
[NB400-106 PLTP] Pahl MV, Ni Z, Sepassi L, et al. Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD). Nephrol Dial Transplant 2009;24(8):2541-2546. [PMID: 19297356]

[NB400-111 Endothelial Lipase] Wiersma H, Gatti A, Nijstad N, et al. Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice. J Lipid Res 2009;50(8):1571-1580. [PMID: 19252221]

[NB400-157 Liver X Receptor] Dang H, Liu Y, Pang W, et al. Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J. Biol. Chem. 2009 284(10): 6218-6226. [PMID: 19119143]

[NB400-148 NPC1] Podechard N, Le Ferrec E, Rebillard A, et al. NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons. Cardiovasc Res 2009;82(2):361-370. [PMID: 19131362 ]