Hypoxia eNews - 1st Edition

Conferences and Events
Novus is proud to sponsor the AACR Special Conference: Metabolism and Cancer which includes presentations on the following hypoxia-related topics:

Session 3: Transcriptional Control of Metabolism I: HIF
Chairperson: M. Celeste Simon, University of Pennsylvania
Monday, September 11. 2009 3:00 p.m.-5:00 p.m.

•Oxygen-dependent regulation of glucose, energy, and redox homeostasis by
  hypoxia-inducible factor 1
  Gregg L. Semenza, Johns Hopkins University

•HIF-2 alpha inhibition promotes p53 pathway activity, tumor cell death, and
  radiation responses
  M. Celeste Simon, University of Pennsylvania
    
•The integration of signaling through HIF
  Randy Johnson, University of California, San Diego

New Product Information
•25% OFF Select Hypoxia Antibodies. View the list here.

•HIF-1 alpha is now available conjugated to Dylight 488™, DyLight 549™ and
  DyLight 649™. View the available Hypoxia products here.

Coming Soon: Customer Reviews Published on our Website
•Hif-1 Alpha Antibody (catalog number: NB100-131) was tested in   immunohistochemistry-paraffin on human melanoma at a 1:1,000 dilution.Customer   said that “at this dilution there is still some background, but the nuclear staining is   very clear."

•Hif-1 Alpha Antibody (catalog number: NB100-449) was tested in western blot on   mouse neuroblastoma at a 1:500 dilution.  The customer rated this antibody with   five stars!

Spotlight on NOX4
Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhance insulin signal transduction.

NOX4 Publications
1. Basuroy S, Bhattacharya S, Leffler CW, et al. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol 2009;296(3):C422-432 [PMID: 19118162]

2. Kim J, Park J-W, Park KM. Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 2009;296(5):F1202-1211. [PMID: 19193722]

3. Maranchie JK, Zhan Y. Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res. 2005 Oct 15;65(20): 9190-3. [PMID: 16230378]

New Publications of Novus' Hypoxia Antibodies
[NB100-123 HIF-1 alpha] Aubert S, Fauquette V, Hemon B, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res 2009;69(14):5707-5715. [PMID: 19549898]

[NB100-417 Carbonic Anhydrase IX] Chen J, Kobayashi M, Darmanin S, et al. Hypoxia-mediated up-regulation of pim-1 contributes to solid tumor formation. Am J Pathol 2009;175(1):400-411. [PMID: 19528349]

[NB100-105 HIF-1 alpha] Fang H-Y, Hughes R, Murdoch C, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009;114(4):844-859. [PMID: 19454749]