Newsletters

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Signaling and Stress

The Unfolded Protein Response (UPR) is a cellular stress response related to the Endoplasmic Reticulum (ER). It is critical that a fine balance between the protein load and the folding capacity is maintained. The accumulation of unfolded or misfolded proteins in the ER leads to ER stress and activates the UPR.

Three ER proteins act as stress sensors - IRE1,...

Cell Cycle Checkpoints and Cancer

Autophagy has been shown to play a role in various physiological processes such as adaptation to starvation, cell differentiation, tumor suppression, adaptive immunity, and cell death etc. Autophagy not only preserves cellular homeostasis but also controls intracellular pathogens, ranging from unicellular organisms to humans. Autophagy therefore represents one of the most primitive examples of innate immune responses.

Autophagy has been well integrated with immune...

Cell Cycle Checkpoints and Cancer

Webinar Join us on Thursday, October 30th at 9:00am MST for our latest neuroscience webinar titled “Antibodies for the Characterization of Neural Stem Cell Lines”.  Registration is now open...
Hypoxia eNews

Hypoxia inside solid tumors has been associated with tumor progression and therapy resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of the role of hypoxia in these phenomena. HIF-1 alpha is the master transcriptional factor, which binds to HIF-1 beta upon hypoxia to activate the transcription of...

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