Autophagy eNews - 1st Edition

New Product Information
25% OFF Autophagy-related antibodies! View the list here.

Coming Soon: Customer Reviews Published on our Website ATG9A Antibody [NB110-56893]

This antibody was recently given a review of 5 stars, in a review submitted September 8, 2009.  The customer used the antibody in Western Blot on human brain extract within the suggested dilution and achieved a specific band at 90 kDa. The customer stated “I was very happy to use the product and another one for LC3 from your company and would gladly recommend it for anyone interested.”

  Reviewed by Panaiyur S. Mohan, Ph.D. (mohan@nki.rfmh.org)

Spotlight on ATG5
ATG5 is known to modulate T-cell survival and therefore plays an important role in Multiple Sclerosis, where T-cells mediate demylenation. (Alirezaei M, et al. Autophagy 2009, 5(2): 152-58) Furthermore, as many as 699 genes are differentially expressed in ATG5 sufficient versus deficient thymocytes.  (Stephenson LM, et al. Autophagy 2009, 5(5):625-35)  Given these findings, ATG5’s role in basic Neuroscience and Autoimmune research is rapidly expanding.

See all ATG5 antibodies and proteins offered by Novus Biologicals here

Publications
[NB110-53818 ATG5] Lee J-A, Gao F-B. Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia. J Neurosci 2009;29(26):8506-8511. [PMID: 19571141]

[NB100-2220 LC3] Fan S, Meng Q, Saha T, et al. Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner. Cancer Res 2009;69(15):6083-6091. [PMID: 19622773]

[NB600-1384 LC3B] Yu WH, Dorado B, Figueroa HY, et al. Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric alpha-Synuclein. Am J Pathol 2009;175(2):736-747. [PMID: 19628769]

Conferences/Events
Visit Novus at Neuroscience in Chicago, Booth 1719 to find out about the latest Autophagy Antibodies!