Apoptosis eNews - 1st Edition

Spotlight on Bcl-2
Bcl-2 suppresses apoptsois by controlling mitochondrial membrane permeability and inhibiting caspase activity by forming pores in the mitochondrial outer membrane.  Despite Bcl-2’s known role in the mitochondrial mediated pathway of apoptosis, it is unknown whether Bcl-2 forms monomeric or oligomeric pores.  A recent study shows that the Bcl-2 pore expands as the concentration of Bcl-2 increases, thus suggesting that the pore is formed by Bcl-2 oligomers (Peng J, et al. Apoptosis. 2009;14(10):1145-53).  Bcl-2 formed pores are much smaller than the pores created via Bax action, therefore the oligomerization findings in this study support the model that Bcl-2 is a defective Bax.

Bcl-2 Antibodies:

	Bcl-2 [Ser70] Antibody – NBP1-02683
	Bcl-2 (BCL/10C4) Antibody – NB100-78543
	Bcl-2 Antibody – NB100-78342
	Bcl-2 [Thr56] Antibody – NBP1-02865

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Coming Soon: Customer Reviews Published on our Website

IRE-1 Alpha Phosphospecific Antibody [NB100-2323]

NB100-2323 was given 5 stars in a customer review submitted on May 27, 2009. The customer conducted Western blot analysis on mouse lens tissue at a dilution of 1:1,000. A specific band was visualized at 110 kDa.

New Product Information
25% OFF select apoptosis-related antibodies and proteins. View the list here.

Publications
[cIAP2 NBP1-27972]  Bertrand MJ, et al. Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity. 2009 Jun;30(6):789-801. [PMID: 19464198]

[IRE-1 alpha NB100-2323] Kashiwakura Y, et al. Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and smad regulates REIC/Dickkopf-3-Induced apoptosis. Cancer Res. 2008 Oct;68(20):8333-8341. [PMID: 18922905]

[PERP NB500-231] Singaravelu K, et al. PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. Am J Physiol Renal Physiol. 2009 Apr;296(4):F847-858 [PMID: 19158346]

[Survivin NB500-201]  Song KY, et al. Expression of the antiapoptosis gene survivin predicts poor prognosis of stage III gastric adenocarcinoma. Jpn J Clin Oncol. 2009 May;39(5):290-296. [PMID: 19336448]

[TRAIL NB500-220] Herzer K, Hofmann TG, Teufel A, et al. IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Cancer Res. 2009 Feb;69(3):855-862. [PMID: 19141642]