anti-DNA repair protein XRCC3 antibody, anti-XRCC 3 antibody, anti-X ray repair cross complementing protein 3 antibody, anti-X ray repair complementing defective repair in Chinese hamster cells 3 antibody, anti-X ray repair complementing defective repair in chinese hamster antibody,
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
100-165 reacts with human XRCC3. Other species have not been tested.
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Uses:
By Western blot, this antibody recognizes a band at 38 kDa representing XRCC3. No cross-reactivity was observed with XRCC2, RAD51, RAD51B, RAD51C, or RAD51D.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Five human RAD51 homologs have been identified: XRCC2, XRCC3, RAD51B, RAD51C, and RAD51D. Each of these homolgs interacts with one or more of the others, with all of the proteins involved in one complex or multiple smaller complexes.
XRCC3 (x-ray cross complementing) was first identified as a human gene complementing the DNA damage sensitivity, chromosonal instability and impaired growth of the mutant hamster cell line irs1SF. This fact coupled with XRCC3 being a member of the RAD51 gene family have implied a role in the repair of DNA damage by homologous recombination.
Thacker, J. A surfeit of RAD51-like genes? Trends Genet. 15(5): 166-8, 1999.
Brenneman, M.A., et al. XRCC3 is required for efficient repair of chromosone breaks by homolgous recombination. Mutation Research. 459(2): 89-97, 2000. (Hamster)