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WWOX Antibody

 (5 Publications)
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Product Details

Summary
Product Discontinued
View other related WWOX Primary Antibodies

Order Details


    • Catalog Number
      NB200-178
    • Availability
      Product Discontinued

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WWOX Antibody Summary

Immunogen
A synthetic peptide corresponding to residues 89-107 [RLAFTVDDNPTKPTTRQRY] of the human protein.
Specificity
WW domain-containing oxidoreductase
Clonality
Polyclonal
Host
Rabbit
Gene
WWOX
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/ Immunofluorescence 1:1000
  • Immunohistochemistry 1:100-1000
  • Immunohistochemistry-Frozen 1:100-1000
  • Immunohistochemistry-Paraffin 1:100-1000
  • Immunoprecipitation 3ug / ml
  • Western Blot 1:500-5000
Control
WWOX Overexpression Lysate
Publications
Read Publications using
NB200-178 in the following applications:

  • IF
    1 publication
  • IHC-P
    4 publications
  • WB
    1 publication

Reactivity Notes

Reacts with human, mouse, chimpanzee and orangutang.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for WWOX Antibody

  • D16S432E
  • EC 1.1.1
  • EC 1.1.1.-
  • FOR
  • FORHHCMA56
  • FRA16D
  • Fragile site FRA16D oxidoreductase
  • SDR41C1
  • short chain dehydrogenase/reductase family 41C, member 1
  • WOX1
  • WOX1PRO0128
  • WW domain containing oxidoreductase
  • WW domain-containing oxidoreductase
  • WW domain-containing protein WWOX
  • WWOX

Background

WW domain-containing oxidoreductase (WWOX) is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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WWOX Antibody
NB200-178
WWOX Antibody
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IP

Publications for WWOX Antibody (NB200-178)(5)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IF, IHC-P, WB.


Filter By Application
IF
(1)
IHC-P
(4)
WB
(1)
All Applications
Filter By Species
Human
(4)
All Species
Showing Publications 1 - 5 of 5.
Publications using NB200-178 Applications Species
Bendinelli P, Maroni P, Matteucci E, Desiderio MA. HGF and TGFB1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells Mol. Cancer. 2015-06-04 [PMID: 26041563] (IHC-P, Human)

Details:
WWOX antibody (Imgenex: IMG-4187) was used at 1:200 dilution on sections from human bone metastasis and primary breast carcinoma [serial sections of pair-matched human specimens from primary-invasive ductal breast carcinoma (positive for oestrogen and progesterone receptors and negative for HER2) and from bone metastasis] (Fig. 7), as well as from bone metastasis and the bone marrow of the 1833 cells xenograft model (Figure S3). 		IHC-P Human
Winardi W, Tsai CY, Chen WT et al. Reduced WWOX protein expression in human astrocytoma. Neuropathology 2013-12-01 [PMID: 23675860] (IHC-P, Human) IHC-P Human
Li YP, Wu CC, Chen WT et al. The expression and significance of WWOX and B-catenin in hepatocellular carcinoma. APMIS. 2013-02-01 [PMID: 23030478]
Maeda N, Semba S, Nakayama S et al. Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations. Virchows Arch. 2010-10-01 [PMID: 20737170] (IF, IHC-P, WB, Human)

Details:
WB: Fig 1B (normal gastric mucosa and gastrocarcinoma (GC) cell lines, Fig 2B (GC), Fig 3A (Adenovirus-WWOX infected HSC-59 GC cells). IF: Fig 1C (GC cells). IHC (P): Fig 4A (GC human tumors and normal gastric mucosa), Table 1 (WWOX expression correlation 		IF, IHC-P, WB Human
Nakayama S, Semba S, Maeda N et al. Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas. Br J Cancer. 2009-05-05 [PMID: 19352382] (IHC-P, Human)

Details:
IHC (P): Human pancreatic tumor tissue (Figs 1 and 3; Tables I and II). 		IHC-P Human

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Product General Protocols

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Video Protocols

WB Video Protocol
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FAQs for WWOX Antibody (NB200-178). (Showing 1 - 1 of 1 FAQs).

  1. I have a question on anti-WWOX antibody NB200-178. How was the antibody purified and what proteins are present in the product as it is offered. Is it purely IgG?
    • NB200-178 is immunogen affinity purified and is supplied in PBS with 0.02% sodium azide. It does not contain any carrier proteins so the rabbit antibody is the only protein expected to be present.

Control Lysate(s)

WWOX Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol WWOX
Entrez
Uniprot