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WNK1 Antibody

 (1 Publication)
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Product Details

Summary
Product Discontinued
View other related WNK1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-32917
    • Availability
      Product Discontinued

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WNK1 Antibody Summary

Immunogen
Recombinant fragment corresponding to a region within amino acids 44 and 328 of WNK1 (Uniprot ID#Q9H4A3)
Localization
Secreted
Specificity
Human WNK1. The immunogen recognition regions are present in Isoforms 1, 2, 4 (HSN2), and 5.
Clonality
Polyclonal
Host
Rabbit
Gene
WNK1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
Publications
Read Publication using NBP1-32917.

Reactivity Notes

Tested in human. Not yet tested in any other species.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Purity
Immunogen affinity purified

Alternate Names for WNK1 Antibody

  • EC 2.7.11
  • EC 2.7.11.1
  • Erythrocyte 65 kDa protein
  • HSAN2hereditary sensory neuropathy, type II
  • HSN2MGC163339
  • hWNK1
  • KDP
  • KDPMGC163341
  • KIAA0344
  • Kinase deficient protein
  • p65
  • PHA2C
  • PRKWNK1
  • PRKWNK1PSK
  • prostate-derived sterile 20-like kinase
  • Protein kinase lysine-deficient 1
  • Protein kinase with no lysine 1
  • protein kinase, lysine deficient 1
  • serine/threonine-protein kinase WNK1
  • WNK lysine deficient protein kinase 1
  • WNK1

Background

WNK lysine deficient protein kinase 1 (WNK1) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. WNK1 is responsible for controling Na+ and Cl- ion transport by inhibiting the activity of other related protein kinases, such as WNK4.

WNK1 mutations have been associated with Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II) and congenital sensory neuropathy.

WNK1 is also known as Human Accelerated Region 5, and is thought to have played a key role in differentiating humans from apes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for WNK1 Antibody (NBP1-32917)(1)

We have publications tested in 1 confirmed species: Human.


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FAQs for WNK1 Antibody (NBP1-32917). (Showing 1 - 1 of 1 FAQ).

  1. What is the sequence of the immunogen for NBP1-32917?
    • The immunogen for NBP1-32917 maps to a region found between amino acids 44-328 of WNK1. The sequence in itself is proprietary and cannot be disclosed.

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Bioinformatics

Gene Symbol WNK1
Entrez
Uniprot