Vitamin D Receptor Antibody 0.05 mg

Vitamin D Receptor NBP1-61794

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Ordering Information: NBP1-61794

Catalog NumberNBP1-61794
  • FormUnconjugated
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Vitamin D Receptor Antibody Summary

 
Species Human
Tested Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality Polyclonal
Host Rabbit
Gene VDR
Purity Immunogen affinity purified
Specificity Vitamin D Receptor (Ab-208) Antibody detects endogenous levels of total Vitamin D Receptor protein.
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Vitamin D Receptor Antibody Details

 
Immunogen The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor. The immunogen region is: Internal.

Species Reactivity

 
Human

Applications/Dilutions

 
Dilutions
  • Western Blot 1:500-1:1000
  • ELISA 1:10000
  • Immunocytochemistry/Immunofluorescence 1:100-1:500
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
Molecular Weight

48 kDa

Product PDFs

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Research Tools

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Packaging, Storage & Formulations

 
Storage Store at -20C. Avoid freeze-thaw cycles.
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
Unit Size 0.05 mg (also available in 0.1 mg)
Concentration 1 mg/ml
Preservative 0.02% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol VDR
Entrez
Uniprot

Alternate Names for Vitamin D Receptor

 
  • vitamin D3 receptor
  • NR1I1Nuclear receptor subfamily 1 group I member 11,25-dihydroxyvitamin D3 receptor
  • vitamin D1,25- dihydroxyvitamin D3 receptor

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Background

 
The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally-specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9- cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.