VEGFR1/Flt-1 Antibody (Y103)

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

VEGFR-1 (vascular endothelial growth factor receptor 1) is a 180-kDa membrane receptor tyrosine kinase that is the receptor for vascular endothelial growth factor (VEGF), VEGFB and PGF. VEGF is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions (1). VEGFR-1 has seven extracellular Ig-like domains; the second domain from the N-terminus is necessary and sufficient for high affinity VEGF binding (2). The biological effects of VEGF are mediated by VEGFR-1 and VEGFR-2 (1), and two major tyrosine phosphorylation sites at Tyr 1213 and Tyr 1242 and two minor tyrosine phosphorylation sites at Tyr 1327 and Tyr 1333 exist in VEGFR-1 (3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, WB.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB110-57643	Applications	Species
Mansour, SG;Zhang, WR;Moledina, D;Coca, SG;Jia, Y;Thiessen-Philbrook, H;McArthur, E;Inoue, K;Koyner, JL;Shlipak, MG;Wilson, FP;Garg, AX;Ishibe, S;Parikh, CR;, ; The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery Am. J. Kidney Dis. 2019-04-05 [PMID: 30955944] (ICC/IF, Human)	ICC/IF	Human
Gibbins KJ, Gibson-Corley KN, Brown AS et al. Effects of excess thromboxane A2 on placental development and nutrient transporters in a Mus musculus model of fetal growth restriction Biol. Reprod. 2018-01-17 [PMID: 29351577] (Mouse)		Mouse
Iinuma H, Fukushima R, Inaba T et al. Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients. J Transl Med 2014-04-11 [PMID: 24708624] (IHC-P, Human)	IHC-P	Human
Ramasamy SK, Kusumbe AP, Wang L, Adams RH. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature 2014-03-20 [PMID: 24647000] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Frank NY, Schatton T, Kim S et al. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res 2011-02-01 [PMID: 21212411]
Yu L, Baxter PA, Voicu H et al. A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo . Neuro Oncol 12 580-594. 2010-01-01 [PMID: 20511191] (IF/IHC)	IF/IHC
Kosugi T, Nakayama T, Li Q et al. Soluble-Flt-1 Gene Therapy Ameliorates Albuminuria, but Accelerates Tubulointerstitial Injury in Diabetic Mice . Am J Physiol Renal Physiol. 2009-01-01 [PMID: 20015944]
Sato W, Kosugi T, Zhang L et al. The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy . Laboratory Investigation 88 949-961. 2008-01-01 [PMID: 18607348] (WB, IF/IHC)	WB, IF/IHC
Cimpean AM, Raica M, Encicab S et al. Immunohistochemical expression of vascular endothelial growth factor A (VEGF), and its receptors (VEGFR1, 2) in normal and pathologic conditions of the human thymus . Ann Anat 190 238-245. 2008-01-01 [PMID: 18356031] (IF/IHC)	IF/IHC
Herring A, Yasin H, Ambree O et al. Environmental Enrichment Counteracts Alzheimer’s Neurovascular Dysfunction in TgCRND8 Mice . Brain Pathology 18 32-39. 2008-01-01 [PMID: 17924982] (WB, IF/IHC)	WB, IF/IHC
Amura CR, Brodsky KS, Groff R et al. VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/- ) mice . Am J Physiol Cell Physiol 293 C419-C428. 2007-01-01 [PMID: 17475663] (WB)	WB
Show All 11 Publications. Collapse Publications.

Array NB110-57643

• VEGFR1/Flt-1 Antibodies
• VEGFR1/Flt-1 ELISA Kits
• VEGFR1/Flt-1 Proteins
• VEGFR1/Flt-1 ELISAs
• VEGFR1/Flt-1 Proteins and Enzymes