The active metabolite of vitamin D modulates the expression of a wide variety
of genes in a developmentally-specific manner. This secosteroid hormone
can up- or downregulate the expression of genes involved in a diverse array
of responses such as proliferation, differentiation and calcium homeostasis.
1,25-(OH)2-vitamin D3 exerts its effects through interaction with the vitamin D
receptor (VDR), a member of the superfamily of hormone-activated nuclear
receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-
cis retinoic acid receptor, RXR, and affects gene expression by binding specific
DNA sequences known as hormone response elements, or HREs. In addition
to regulating the above-mentioned cellular responses, 1,25-(OH)2-vitamin D3
exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma
and breast carcinoma cells.
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FAQs for VDR/NR1I1/Vitamin D Receptor (2)
In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
I was wondering what does Format 7C mean as far as anitbodies go?
7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)