Titin Antibody (4D8)

Species: Hu Applications: WB, ELISA Clonality: Monoclonal	Gene: TTN Purity: IgG purified Host: Mouse
Specificity: TTN - titin
See All Titin Products See All Titin Related Products: Peptides and Proteins Primary Antibodies RNAi
*Note not all species have been tested for reactivity. Only those species listed have been tested. We cannot make any guarantees about additional reactivities or cross reactivities beyond those that have been tested. This antibody may or may not react with other species.

Clone:	4D8
Isotype:	IgG Mix Kappa
Immunogen:	TTN (AAH58824, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag.
Epitope:	MTTQAPTFTQPLQSVVVLEGSTATFE AHISGFPVPEVSWFRDGQVISTSTLP GVQISFSDGRAKLTIPAVTKANSGRY SLKATNGSGQATSTAELLVKAETAPP NFVQRL*

Entrez:	7273 (Human)
Omim:	188840, 600334, 604145, 608807, (Human)
Swiss Prot:	AAH58824 (Human)
Related Genes:	MYH14, NEB, DES, CAPN3, TCAP, FN1, AFM, ANKRD1, DMD, VCL, KCNT1, CHRNA2, HLA-E, MYBPC3, CSRP3, TRIM63, COG3, BRAF, GSN, VIM, MYOM2, ANKRD2, MYOT, MARCKSL1, OBSCN, TNF, PSMA1, FAM188A, CAR8, C2, HNRNPC, CA8, GFAP, CFB, EIF3K, TNC, NOTCH2, CALM3, CALM2, CALM1

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. A N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere respectively so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Of the many titin variants identified, five for which complete transcript information is available are described. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9 and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

Reactivity:	Human. Other species not tested.

Uses:	Antibody Reactive against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
Dilutions:	ELISA, Western Blot 1:500

This product is produced by and distributed for Abnova, a company based in Taiwan.

Storage:	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Preservative:	No Preservative
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.