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Thyroglobulin Antibody (NB120-6228)

Thyroglobulin Antibody (TGB04)

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Thyroglobulin Antibody (TGB04) Summary:
Species:Ca, Hu, Mu, Rt
Applications:IHC-P
Clonality:Monoclonal
Gene:TG
Purity:Ascites
Host:Mouse
Specificity:This is specific to 330 kD protein.
Publications:Antibody has at least 3 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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Thyroglobulin Antibody (TGB04) Details:
Clone:TGB04
Isotype:IgG1
Immunogen:BALB/C mice were injected with purified human thyroglobulin.
Localization:Secreted
Species Reactivity:

Cross-reacts with Dog, Human, Mouse and Rat. Not yet tested in other species.

Applications:
Uses:IHC-P: Use at an assay dependent dilution.
Dilutions:Immunohistochemistry-Paraffin
Unit Size:0.5 ml
Concentration:This product is unpurified. Concentration is not relevant.
Positive Controls:1 Positive Controls
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:Constituents: PBS
Preservative:0.05% Sodium Azide
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: TG
Entrez7038 (Human)
21819 (Mouse)
24826 (Rat)
 
Background:

Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid. Thyroglobulin is the glycoprotein precursor to the thyroid hormones. Its synthesis and metabolism have seemingly wasteful features. It has a molecular weight of 660,000, with 2 identical subunits of MW 300,000 and 10% sugars; yet its complete hydrolysis yields only 2 to 4 molecules of the iodothyroxines T4 and T3. Baas et al. (1986) showed that the TG gene encodes an 8.7-kb mRNA, covers at least 300 kb of genomic DNA and contains at least 37 exons separated by introns as large as 64 kb. A striking structural difference between the 5-prime and 3-prime parts of the gene suggested that it is composed of 2 evolutionarily different regions. The first 30 kb of DNA encodes 3 kb of the mRNA yielding an exon:intron ratio of 1:10, whereas the remaining 270 kb encodes 5.7 kb of the mRNA with a ratio of 1.47.
Images (1)
  • Formalin fixed paraffin embedded human thyroid stained with Thyroglobulin antibody.

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3 Background References
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Working with Thyroglobulin

Thyroglobulin Antibody (TGB04) Images (1)
Formalin fixed paraffin embedded human thyroid stained with Thyroglobulin antibody.
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Publications (3)

Thyroglobulin Antibody (TGB04) Background References:

  1. Skalli O et al. A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 103:2787-96 (1986).
  2. Baas F et al. The human thyroglobulin gene is over 300 kb long contains introns of up to 64 kb. Nucleic Acids Res 14:5171-86 (1986).

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Thyroglobulin in Context

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Novus Explorer for Thyroglobulin gene
Try our bioinformatic tool that shows the relationships between TG and other genes, diseases, pathways and post-translational modifications.