Thyroglobulin Antibody (NBP1-22934)
Thyroglobulin Antibody (RBU/01)
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anti-AITD 3 antibody, anti-Tgn antibody, anti-TG antibody, anti-hTG antibody, anti-AITD3 antibody |
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Thyroglobulin Antibody (RBU/01) Summary: | | Gene: | TG |
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| Purity: | Ascites |
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| Host: | Mouse |
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| | Specificity: | This antibody is specific to the 330 kD protein. Thyroglobulin is synthesized by follicular epithelial cells of the thyroid. Thyroglobulin has been useful in the positive identification of thyroid carcinomas of the papillary and follicular types. It stains thyroglubulin in adenoma from thyroid (microfollicles). This antibody cross-reacts with human, bovine, porcine, goat, and guinea pig thyroglobulin. |
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| Publications: | Antibody has at least 4 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Thyroglobulin Products Thyroglobulin Antibody (RBU/01) Details: | Clone: | RBU/01 |
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| Isotype: | IgG1 |
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| Immunogen: | BALB/C mice were injected with purified human thyroglobulin. |
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| Localization: | Cytoplasmic |
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Human, Bovine, Porcine, Goat, and Guinea pig |
| Uses: | Immunohistochemistry-Paraffin
Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients? clinical histories and other relevant diagnostic tests should be utilized by a qualified person(s) when evaluating and interpreting results.
Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. Optimal incubation conditions should be determined by the user based upon the fixation conditions and staining system employed. Suitable for formalin fixed paraffin embedded tissues. No special pretreatment is required. |
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| Dilutions: | Immunohistochemistry-Paraffin |
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| Unit Size: | 1 ml |
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| Concentration: | This product is unpurified. Concentration is not relevant. |
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| Positive Controls: | 1 Positive Controls |
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Notes: Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients? clinical histories and other relevant diagnostic tests should be utilized by a qualified person(s) when evaluating and interpreting results. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. Optimal incubation conditions should be determined by the user based upon the fixation conditions and staining system employed. Suitable for formalin fixed paraffin embedded tissues. No special pretreatment is required. Packaging: | Storage: | Store at 4 °C. Do not freeze. |
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| Preservative: | Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
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Thyroglobulin Antibody (RBU/01) Images (0)
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Publications (4)Thyroglobulin Antibody (RBU/01) Background References:- 4) O?Byrne et al. Br J cancer 82: 1427, 2000.5) Ossendrop et al. J Immunol Methods 120: 191, 1989.
- 3) Skalli et al. J Histo Chem 37: 315, 1989.
more... - 2) Skalli et al. Lab Invest 60: 275, 1989.
- 1) Richardson TC et al. Histochem 86 (4):437, 1987.
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Related ProductsPositive Controls| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Other Positive Controls |
Peptides and ProteinsPrimary Antibodies (25)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Thyroglobulin Antibody (EPR3614) | NBP1-40694 | Hu | IHC-P, IP, WB | (2) | | | | | Thyroglobulin Antibody (TGB04) | NB120-6228 | Ca, Hu, Mu, Rt | IHC-P | (1) | (3) | | | | Thyroglobulin Antibody (14/14) | NBP1-42112 | Hu, Mu, Rt | ELISA, IHC-P | | | | | | Thyroglobulin Antibody (12G9) | NB110-8084 | Bv, Ca, Fe, Hu, Mu, Po, Rt | ELISA | | | | | | Thyroglobulin Antibody (EPR3615) | NBP1-40695 | Hu | IP, WB | (1) | | | | | ... and 20 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Mouse IgG Antibody [Biotin] | NB720-B | Mu | ELISA, IHC-P, WB | | | | | | Mouse IgG Antibody [HRP] | NB720-H | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [Alkaline Phosphatase] | NB720-AP | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [FITC] | NB720-F | Mu | ICC, IHC-P | | (2) | | | | Mouse IgG Antibody | NB120-7056 | Bv(-), Ch(-), Eq(-), Gp(-), Gt(-), Ha(-), Hu(-), Mu, Rb(-), Rt(-), Sh(-) | ELISA, IHC-P, IP, WB | | | | | | See All » |
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