TYRO3 Antibody 0.1 ml

TYRO3 NBP1-28635

Contact Information

Choose a country to view pricing and purchasing information.

More on NBP1-28635

  • All TYRO3 Products
  • Alternate Names
     
  • Submit a Review

Ordering Information: NBP1-28635

Catalog NumberNBP1-28635
  • FormUnconjugated
  • Formats
  • Size(s)
  • Price, Shipping
    & Availability
     

     
  •  

TYRO3 Antibody Summary

 
Species Human, Mouse
Predicted Species Rat (94%). Backed by our 100% guarantee.
Tested Applications WB, ICC/IF
Clonality Polyclonal
Host Rabbit
Gene TYRO3
Purity Immunogen affinity purified
Guarantee Plus All of our products are backed by our 100% guarantee to work for stated and predicted species and applications.
Innovator's Reward Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

TYRO3 Antibody Details

 
Immunogen Synthetic peptide made to an internal portion of the human TYRO3 protein (within residues 100-250). [Swiss-Prot# Q06418]
Localization Cell membrane; Single-pass type I membrane protein.

Species Reactivity

 
Human and mouse. Immunogen sequence has 94% identity to rat.

Applications/Dilutions

 
Dilutions
  • Western Blot 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:200
Application Notes

This TYRO3 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~96 kDa.

Molecular Weight

96 kDa

Positive Controls

2 Positive Controls

Other Available
Formats
Alexa Fluor (R) 405 Labeled NBP1-28635AF405
Alexa Fluor (R) 488 Labeled NBP1-28635AF488
Alexa Fluor (R) 647 Labeled NBP1-28635AF647
Alexa Fluor (R) 700 Labeled NBP1-28635AF700
Biotin Labeled NBP1-28635B
DyLight 405 Labeled NBP1-28635V
DyLight 488 Labeled NBP1-28635G
DyLight 550 Labeled NBP1-28635R
DyLight 650 Labeled NBP1-28635C
FITC Labeled NBP1-28635F
HRP Labeled NBP1-28635H
Learn about Custom Antibody Labeling
Control Peptide
TYRO3 Peptide (NBP1-28635PEP)

Product PDFs

Reviews

Earn rewards points by submitting your review for TYRO3 Antibody (NBP1-28635).
Submit a Review

Publications

Earn rewards if you have published using TYRO3 Antibody (NBP1-28635).
Submit a Publication

Protocols and FAQs

Controls & Support Products

Research Tools

View all TYRO3 Research Tools.

Packaging, Storage & Formulations

 
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer PBS, 30% glycerol
Unit Size 0.1 ml (also available in 0.025 ml (sample size))
Concentration 1.29 mg/ml
Preservative 0.1% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol TYRO3
Entrez
Uniprot

Alternate Names for TYRO3

 
  • BYK
  • EC 2.7.10
  • Tyrosine-protein kinase SKY
  • SKY
  • Tyrosine-protein kinase RSE
  • DTK
  • Tyrosine-protein kinase DTK
  • tyrosine-protein kinase receptor TYRO3
  • Tyrosine-protein kinase byk
  • FLJ16467
  • Tif
  • Brt
  • Sky
  • EC 2.7.10.1
  • Dtk
  • RSE
  • TYRO3 protein tyrosine kinase

Related Products by Gene

Background

 
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a RTK which facilitate transduction of signals from extracellular matrix (ECM) into cytoplasm via its direct interaction with multiple ligands such as TUB, TULP1 or GAS6 for the regulation of multiple biological processes such as cell survival, migration and differentiation. TYRO3-ligand binding stimulates its dimerization as well as autophosphorylation on its intracellular domain that provides docking sites for the molecules of downstream signaling. Once stimulated, TYRO3 interacts with PIK3R1 leading to increased PI3K activity followed by AKT signaling activation including NFkB nuclear translocation mediated up-regulation of transcription of NFkB's target genes. TYRO3 signaling events are critical to neuron protection from excitotoxic injury, platelet aggregation, cytoskeletal reorganization, inhibition of TLRs-mediated innate immune response via STAT1 activation followed by production of cytokine signaling suppressors (SOCS1 and SOCS3). TYRO3 is highly expressed during CNS neurogenesis with distinct patterns in adult brain and has been closely related to CNS immunodysfunction.