TYRO3 Antibody (NBP1-28635) | Novus Biologicals

TYRO3 Antibody (NBP1-28635) ( 0.1 ml)

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	Catalog Number	NBP1-28635 (Sample Size Available)
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anti-BYK antibody, anti-EC 2.7.10 antibody, anti-Tyrosine-protein kinase SKY antibody, anti-SKY antibody, anti-Tyrosine-protein kinase RSE antibody, anti-DTK antibody, anti-Tyrosine-protein kinase DTK antibody, anti-tyrosine-protein kinase receptor TYRO3 antibody, anti-Tyrosine-protein kinase byk antibody, anti-FLJ16467 antibody, anti-Tif antibody, anti-Brt antibody, anti-Sky antibody, anti-EC 2.7.10.1 antibody, anti-Dtk antibody, anti-RSE antibody, anti-TYRO3 protein tyrosine kinase antibody

TYRO3 Antibody Summary:

Species:	Hu, Mu	Gene:	TYRO3
Applications:	WB, ICC, IF	Purity:	Peptide affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Publications:	NBP1-28635 has at least 3 Background References

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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TYRO3 Antibody Details:

Immunogen:	Synthetic peptide made to an internal portion of the human protein (within residues 100-250). [Swiss-Prot# Q06418]
Localization:	Cell membrane; Single-pass type I membrane protein.

Species Reactivity:

Human and mouse. 100% sequence identity to human and mouse protein, 94% sequence identity to rat protein.

Applications:

Uses:	This antibody is useful for Western blot analysis where a band can be seen at ~96 kDa. This antibody is also useful for immunocytochemistry/immunofluorescence.
Dilutions:	Immunocytochemistry 1:200, Immunofluorescence 1:200, Western Blot 2.0 ug/ml
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	1.29 mg/ml
Positive Controls:	2 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS, 30% glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: TYRO3

Entrez:	7301 (Human)
Uniprot:	Q06418 (Human)

Related Genes:

Background:

Receptor protein tyrosine kinases (RPTKs) are a class of transmembrane signaling molecules. They have been shown to regulate signaling cascades that control synaptic function in the central nervous system (CNS). Tyro3 is one of three RPTKs belonging to the Axl/UFO subfamily, that also includes Axl and Mer. Tyro3 is the most commonly expressed of these receptors in the CNS. It may be involved in the cell adhesion process, and is commonly found in adult tissues with expression mostly in brain, testis, vascular and lymphatic tissue.

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TYRO3 Antibody Images (2)

	Western Blot: TYRO3 Antibody [NBP1-28635] - Lane 1: Western blot on normal human brain, Lane 2: Western blot on normal mouse brain.

	Immunocytochemistry: TYRO3 Antibody [NBP1-28635] - ICC staining of HELA cells using NBP128635 (Green) at a 1:200 dilution detected using Dylight-488 conjugated goat anti-rabbit secondary antibody. Nuclei were visualized using Hoechst 33258 (Blue).

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Publications (3)

TYRO3 Antibody Background References:

3) Zhu, S. et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. PNAS. 2009 Oct 6;106(40):17025-17030.
2) Zheng, Y. et al. NGF-induced Tyro3 Axl function as survival factors for differentiating PC12 cells. Biochem Biophys Res Commun. 2009 Jan 16;378(3):371-5.

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1) Prieto, AL. O'Dell, S. Varnum, B. Lai, C. Localization signaling of the receptor protein tyrosine kinase Tyro3 in cortical hippocampal neurons. Neuroscience. 2007 Dec 5;150(2):319-34