TRF1 Antibody (TRF-78) (NB100-1701)

TRF1 Antibody (TRF-78) (NB100-1701) (0.05 ml)

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	Catalog Number	NB100-1701
	Size(s)	0.05 ml	Price:
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anti-telomeric repeat-binding factor 1 antibody, anti-NIMA-interacting protein 2 antibody, anti-telomeric repeat binding protein 1 antibody, anti-TRBF1 antibody, anti-telomeric repeat binding factor 1 antibody, anti-Telomeric protein Pin2/TRF1 antibody, anti-TRFt-TRF1 antibody, anti-PIN2hTRF1-AS antibody, anti-TRF1FLJ41416 antibody, anti-TTAGGG repeat-binding factor 1 antibody, anti-telomeric repeat binding factor (NIMA-interacting) 1 antibody

TRF1 Antibody (TRF-78) Summary:

Species:	Hu	Gene:	TERF1
Applications:	WB, ELISA, MiAr	Purity:	Protein G purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	TRF1 (TRF-78)
Publications:	NB100-1701 has been mentioned in at least 1 Publication

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TRF1 Antibody (TRF-78) Details:

Clone:	TRF-78
Isotype:	IgG1
Immunogen:	Human TRF1 protein produced in baculovirus.
Localization:	Nuclear
Marker:	Telomere Marker

Species Reactivity:

Cross-reacts with Human. Not yet tested in other species.

Applications:

Uses:	In Western Blot a 70 kDa band is seen.
Dilutions:	ELISA, Microarray, Western Blot 2-4 ug/ml
Unit Size:	0.05 ml
Concentration:	2.0 mg/ml
Positive Controls:	2 Positive Controls

Packaging:

Storage:	Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Buffer:	0.01M PBS [pH 7.4]
Preservative:	15mM Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: TERF1

Entrez:	7013 (Human)
Uniprot:	P54274 (Human)

Related Genes:

Background:

TRF1 binds the double-stranded telomeric repeat sequence, TAGGG. TRF1 and TRF2 are key components of vertebrate telomeres and bind to double-stranded telomeric DNA as homodimers. Dimerization involves the TRF homology (TRFH) domain, which also mediates interactions with other telomeric proteins. Fairall et al. (2001) determined the crystal structures of the dimerization domains from human TRF1 and TRF2 at 2.9- and 2.2-angstrom resolution, respectively. Despite a modest sequence identity, the 2 TRFH domains have the same entirely alpha-helical architecture, resembling a twisted horseshoe. The dimerization interfaces feature unique interactions that prevent heterodimerization. Mutational analysis of TRF1 corroborated the structural data and underscored the importance of the TRFH domain in dimerization, DNA binding, and telomere localization.

Images (2)


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TRF1 Antibody (TRF-78) Images (2)

	Western Blot: TRF1 Antibody (TRF-78) [NB100-1701] - Cell line lysates were separated on SDS-PAGE and probed with 4 µg/mL Monoclonal Anti-TRF1 Clone: TRF-78. Lane 1: HeLa Nuclear, Lane 2: HeLa, Lane 3: HEK-293T, Lane 4: U2OS, Lane 5: HepG2, Lane 6: P19, Lane 7: PC12.

	Immunofluorescence: TRF1 Antibody (TRF-78) [NB100-1701] - HeLa cells stained with 10 µg/mL monoclonal Anti-TRF1 Clone: TRF-78 (NB100-1701). The antibody was developed using Goat Anti-Mouse IgG, Cy3 conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.