TRF1 Antibody (NB110-68281)
TRF1 Antibody (57-6)
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Distributor Data...
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anti-PIN 2 antibody, anti-TERF1 antibody, anti-hTRF1 AS antibody, anti-t-TRF1 antibody, anti-TTAGGG repeat binding factor 1 antibody, anti-TRF antibody, anti-TRF 1 antibody, anti-TRBF1 antibody, anti-TRBF 1 antibody, anti-TERF 1 antibody, anti-telomeric repeat binding protein 1 antibody, anti-telomeric repeat binding factor 1 antibody, anti-Telomeric repeat binding factor (NIMA interacting) 1 antibody, anti-Telomeric protein Pin2/TRF1 antibody, anti-Telomeric protein Pin2 antibody, anti-t TRF1 antibody, anti-PIN2 antibody, anti-NIMA interacting protein 2 antibody, anti-hTRF1-AS antibody, anti-FLJ41416 antibody, |
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TRF1 Antibody (57-6) Summary: | | Gene: | TERF1 |
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| Purity: | Protein G purified |
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| Host: | Mouse |
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| | Specificity: | TRF1 (57-6) - Telomere Marker |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional TRF1 Products TRF1 Antibody (57-6) Details: | Clone: | 57-6 |
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| Isotype: | IgG1 Kappa |
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| Immunogen: | Recombinant TRF1 |
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| Localization: | Nucleus |
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| Marker: | Telomere Marker |
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Human, mouse, rat and monkey. |
| Uses: | This antibody is useful for Western blot analysis where a band can be seen ~60 kDa. Past productions have been useful in ELISA. This antibody is also useful for immunocytochemistry / immunofluorescence. |
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| Dilutions: | ELISA, Immunocytochemistry 1:50-1:200, Immunofluorescence 1:50-1:200, Western Blot 0.5 ug/ml |
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| TMW: | 50 kDa |
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| Unit Size: | 0.1 ml (also available: 0.025 ml (sample size)) |
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| Concentration: | 1.5 mg/ml |
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| Positive Controls: | 3 Positive Controls |
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| Conjugated Antibodies: | 5 Conjugated Antibodies |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Tris-glycine, 150mM NaCl |
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| Preservative: | 0.05% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Telomeric repeat binding factor 1 (TRF1, TERF1, PIN2, TRBF1) and telomeric repeat binding factor 2 (TRF2, TERF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of 5'-TTAGGG-3' to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Downregulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.
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Images (2) Reviews (0) Related Products (28) Exploring TRF1 Working with TRF1
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Working with TRF1
TRF1 Antibody (57-6) Images (2) Western Blot: TRF1 Antibody (57-6) [NB110-68281] - Western blot detection of TRF1. 50 ugs of total lysate each lane. |  Western Blot: TRF1 Antibody (57-6) [NB110-68281] - Detection of TRF1 in HeLa whole cell extracts |
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Jump to: Conjugated Antibodies, Positive Controls, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsConjugated Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| TRF1 Antibody (57-6) [DyLight 488] | NB110-68281G | Hu, Mk, Mu, Rt | ELISA, WB | | | | | | TRF1 Antibody (57-6) [DyLight 550] | NB110-68281R | Hu, Mk, Mu, Rt | ELISA, WB | | | | | | TRF1 Antibody (57-6) [DyLight 650] | NB110-68281C | Hu, Mk, Mu, Rt | ELISA, WB | | | | | | TRF1 Antibody (57-6) [HRP] | NB110-68281H | Hu, Mk, Mu, Rt | ELISA, WB | | | | | | TRF1 Antibody (57-6) [Biotin] | NB110-68281B | Hu, Mk, Mu, Rt | ELISA, WB | | | | |
Positive ControlsLysates (2)Peptides and ProteinsPrimary Antibodies (15)RNAi (2)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Mouse IgG Antibody [Biotin] | NB720-B | Mu | ELISA, IHC-P, WB | | | | | | Mouse IgG Antibody [HRP] | NB720-H | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [Alkaline Phosphatase] | NB720-AP | Mu | ELISA, ICC, IHC-P, WB | | | | | | Mouse IgG Antibody [FITC] | NB720-F | Mu | ICC, IHC-P | | (2) | | | | Mouse IgG Antibody | NB120-7056 | Bv(-), Ch(-), Eq(-), Gp(-), Gt(-), Ha(-), Hu(-), Mu, Rb(-), Rt(-), Sh(-) | ELISA, IHC-P, IP, WB | | | | | | See All » |
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