NB100-63244 recognizes tumour necrosis factor receptor 1-associated death domain protein (TRADD) isoform 2, a 28kDa death domain containing protein. TRADD is expressed in most tissues. It mediates programmed cell death signalling and NF-kappa beta activation through interaction with tumour necrosis factor receptor superfamily, member 1A. By binding the adaptor protein TRAF2, TRADD reduces the recruitment of inhibitor-of-apoptosis proteins, inhibiting TRAF2 mediated apoptosis. TRADD is also involved in the Fas-induced cell death pathway via its interaction with tumour necrosis factor receptor superfamily, member-6/FAS and adaptor protein FADD/MORT1.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:
TRIS buffered saline, pH7.3, 0.5% Bovine Serum Albumin
Preservative:
0.02% Sodium Azide
Limitations:
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.