TGN46 Antibody

The Trans-Golgi network integral membrane protein 2 (TGOLN2) was designated TGN46 based on the predicted molecular mass (46kDa). However, TGN46 is a heavily glycosylated protein, so its molecular weight is often detected at a 110-120kDa. The TGN46 protein is widely expressed. It may be involved in regulating membrane traffic to and from trans-Golgi network, and has been reported as the best available marker for human trans-Golgi network. TGN46 contains a luminal domain, a membrane-spanning domain, and a cytoplasmic domain. The membrane-spanning and cytoplasmic domains contain the retention and retrieval signals, respectively, for localization in the TGN.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 8 of 8.

Publications using NB110-40769	Applications	Species
Dorobantu CM, Albulescu L, Harak C et al. Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathog. 2015-09-01 [PMID: 26406250] (ICC/IF, Human)	ICC/IF	Human
Binda C, Genier S, Cartier A et al. A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate. J Cell Biol. 2014-02-04 [PMID: 24493589] (ICC/IF, Human) Details: TGN46 antibody used for ICC-IF on HEK293 cells transiently transfected with pcDNA3-Flag-DP1 or pcDNA3-L-PGDS-HA (Figure 2).	ICC/IF	Human
Oner SS, Vural A, Lanier SM. Translocation of Activator of G-protein Signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network. J Biol Chem 2013-06-14 [PMID: 23770668] (ICC/IF, Human)	ICC/IF	Human
Frijns E, Kuikman I, Litjens S, Raspe M, Jalink K, Ports M, Wilhelmsen K, Sonnenberg A. Phosphorylation of threonine 1736 in the C-terminal tail of integrin ?4 contributes to hemidesmosome disassembly. Mol Biol Cell23(8):1475-85. 2012-04-01 [PMID: 22357621]
Subathra M, Qureshi A, Luberto C. Sphingomyelin synthases regulate protein trafficking and secretion. PLoS ONE;6(9). 2011-01-01 [PMID: 21980337]
Vire B, David A, Wiestner A. TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation J Immunol 2011-10-15 [PMID: 21908732] (ICC/IF, Human)	ICC/IF	Human
Bacac M, Fusco C, Planche A et al. Securin and separase modulate membrane traffic by affecting endosomal acidification Traffic 2011-05-01 [PMID: 21272169] (WB, Human)	WB	Human
Clarke CJ, Guthrie JM, Hannun YA. Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-{alpha} Involves Protein Kinase C-{delta} in Lung Epithelial Cells. Mol Pharmacol;74(4):1022-1032. 2008-01-01 [PMID: 18653803]

Array NB110-40769

• TGN46 Antibodies
• TGN46 ELISA Kits
• TGN46 Proteins