Survivin Antibody (NB500-201)
Survivin Antibody
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Distributor Data...
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anti-BIRC5 antibody, anti-API4 antibody, anti-TIAP antibody, anti-SVV antibody, anti-IAP4 antibody, anti-EPR 1 antibody, anti-BIRC5 antibody, anti-BIRC 5 antibody, anti-Baculoviral IAP repeat containing protein 5 antibody, anti-Baculoviral IAP repeat containing 5 antibody, anti-Apoptosis inhibitor survivin antibody, anti-Apoptosis Inhibitor 4 antibody, |
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Survivin Antibody Summary: | | Gene: | BIRC5 |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | Specificity: | This is specific for survivin. |
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| Publications: | Antibody has been mentioned in at least 110 Publications. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional Survivin Products Survivin Antibody Details: | Immunogen: | Full-length recombinant human survivin. |
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| Localization: | Nuclear |
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| Marker: | Astrocyte Marker |
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NB 500-201 recognizes human, mouse, rat, feline, and canine survivin. Other species have not been tested. |
| Uses: | By Western blot, this antibody recognizes a band at ~16.5 kDa representing survivin. Immunohistochemistry with cytoplasmic and nuclear detection of survivin can be achieved using formalin-fixed paraffin-embedded tissue sections with prior antigen retrieval (pressure cooking). Other cytochemical applicatons have been tested successfully. This survivin antibody has also been used for Chromatin immunoprecepitation (ChIP) and immunocytochemistry/immunofluorescence. |
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| Dilutions: | Chromatin Immunoprecipitation, Immunocytochemistry, Immunofluorescence 1:50 - 1:500, Immunohistochemistry-Paraffin 1:50 - 1:500, immunoprecipitation, Western Blot 1 ug/ml |
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| Unit Size: | 0.05 ml (also available: 0.025 ml (sample size)) |
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| Concentration: | 0.97 mg/ml |
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| Positive Controls: | 2 Positive Controls |
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| Conjugated Antibodies: | 5 Conjugated Antibodies |
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Packaging: | Storage: | Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles. |
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| Buffer: | Tris-glycine with 150mM NaCl |
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| Preservative: | 0.05% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis.
Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis.
Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
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Images (3) Reviews (5) Related Products (83) Exploring Survivin Working with Survivin
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Jump to: Publications, Images, Reviews, Protocols/Procedures, Ask a Question
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Working with Survivin
Survivin Antibody Images (3) Immunohistochemistry: Survivin antibody [NB500-201] - The top photo is a no primary antibody control stain and the bottom photo is anti-survivin staining of melanoma. Photo courtesy of Dr. Dario Altieri, Yale University. |  Immunofluorescence: Survivn antibody [NB500-201] - Telophase with accumulation of survivin in the midbodies of two daughter cells. Survivin detection using NB 500-201 |  Western Blot: Survivin antibody [NB500-201] - Detection of survivin in HeLa whole cell lysate (30 ug) using NB 500-201 at 1ug/ml (1 minute exposure). |
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Reviewed by:
Anonymous 11/18/2010
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Application:
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Western Blot
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Sample Tested:
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Hela whole cell lysate
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Sample Loaded:
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5-15 µl
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Species:
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Human
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Sample Pretreated:
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RIPA buffer
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Blocking Buffer:
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5% Milk in PBST
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Concentration:
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5%
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Blocking Time:
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1h
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Blocking Temperature:
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20 Celsius
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Dilution Ratio:
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1:1000
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Incubation Time:
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O/N
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Incubation Temperature:
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4? Celsius
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Incubation Dilution Buffer:
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5% Milk in PBST
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Description:
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anti-rabbit IgG
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Manufacturer Catalog #:
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NA9340
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Dilution Ratio:
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1:5000
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Method:
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ECL
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Exposure Time:
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30 sec
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Positive Control:
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-
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Negative Control:
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-
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Did you observe bands?:
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Yes
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Specific Bands:
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17 kDa
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Non-specific Bands:
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- kDa
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Reviewed by:
Anonymous 7/2/2009
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Application:
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Western Blot
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Sample Tested:
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Oswald 1771 Abrams D17 Cancer Cell Lines
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Sample Loaded:
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7-15 ug
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Lot:
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R2
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Blocking Buffer:
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Non Fat Dry Mild in TBST
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Concentration:
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5% NFDM in 1X TBST
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Blocking Time:
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1 hr
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Blocking Temperature:
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20 Celsius
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Dilution Ratio:
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1/1000
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Incubation Time:
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2 hrs
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Incubation Temperature:
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20 Celsius
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Incubation Dilution Buffer:
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1X TBST
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Description:
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Goat anti-Rabbit
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Dilution Ratio:
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1/2000
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Method:
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Fempto Developer
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Exposure Time:
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1-5 seconds
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Positive Control:
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no transfection to knockdown survivin
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Specific Bands:
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18 kDa
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Reviewed by:
surya nauli 6/7/2010
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Application:
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Western Blot
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Sample Tested:
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cancer cells
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Species:
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Mouse
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Reviewed by:
Anonymous 5/4/2010
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Application:
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Western Blot
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Sample Tested:
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Human smooth muscle cells
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Sample Loaded:
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30ug
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Species:
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Human
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Sample Pretreated:
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none
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Results:
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Used the product in Western Blots using human whole cell lysates as well as human mitochondrial extracts. The Survivin band appeared after HRP secondary antibody and chemiluminescence.
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Blocking Buffer:
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5% milk
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Concentration:
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1:1000
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Blocking Time:
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1 hour at room temp
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Blocking Temperature:
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25C Celsius
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Dilution Ratio:
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1:1000
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Incubation Time:
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overnight
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Incubation Temperature:
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4C Celsius
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Incubation Dilution Buffer:
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5% milk
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Description:
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mouse HRP
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Manufacturer Catalog #:
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sigma
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Dilution Ratio:
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1:5000
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Method:
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chemiluminescence
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Exposure Time:
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5 minutes
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Did you observe bands?:
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Yes
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Reviewed by:
Anonymous 8/31/2009
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Application:
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Western Blot
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Sample Tested:
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mouse cell
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Sample Loaded:
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50ug
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Blocking Buffer:
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pbs
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Concentration:
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1
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Blocking Time:
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15 min
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Blocking Temperature:
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70 Fahrenheit
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Dilution Ratio:
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1/200
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Incubation Time:
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over night
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Incubation Temperature:
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4 Celsius
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Incubation Dilution Buffer:
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pbs
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Description:
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rabbit
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Dilution Ratio:
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1/10000
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Method:
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dark room
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Exposure Time:
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1min
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Did you observe bands?:
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True
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Specific Bands:
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17 kDa
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Publications (110)Survivin Antibody Product Specific:- Page BDG, Fletcher S, Yue P, et al. Identification of a Non-phosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain.Bioorganic & Medicinal Chemistry Letters. 2011. In Press, Accepted Manuscript.
- Chiou S-K, Hoa N, Hodges A. Sulindac sulfide induces autophagic death in gastric epithelial cells via Survivin down-regulation: A mechanism of NSAIDs-induced gastric injury.Biochem Pharmacol. 2011 Jun 1;81(11):1317-23. doi: 10.1016/j.bcp.2011.03.019.[PMIC 21458423]
more... - El Ghamrasni S, Pamidi A, Halaby MJ, et al. Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS Genet.PLoS Genet. 2011 May;7(5):e1001385 [PMID 21625617]
- Finkelstein SE, Iclozan C, Bui MM, et al. Combination of External Beam Radiotherapy (EBRT) with Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients. Int J Radiat Oncol Biol Phys. 2011 Mar 11.[PMID: 21398051]
- Lechler P, Balakrishnan S, Schaumburger J, et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 2011 Jul 5.[PMID 21729321]
- Khan S, Jutzy JM, Aspe JR, et al. Survivin is released from cancer cells via exosomes. Apoptosis. 2011 Jan;16(1):1-12. [PMID: 20717727]
- Kim SH, Bommareddy A, Singh SV. Garlic Constituent Diallyl Trisulfide Suppresses X-Linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture and In Vivo. Cancer Prev Res (Phila). 2011 Mar 16. [PMID: 21411500]
- Lechler P, Renkawitz T, Campean V, et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro.BMC Cancer. 2011 Apr 2;11(1):120. [PMID: 21457573]
- Talbot D, Ranson M, Davies J, et al. Tumor Survivin is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof of Concept, First-in-Human Dose Study. Clin Cancer Res. 2010 Nov 12. [PMID: 21041181]
- Xia M, Knezevic D, Vassilev LT. p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. Oncogene. 2010 Sep 27. [PMID: 20871630]
- Y. Lou, Q. Peng, B. Nolan, et al. Oral administration of caffeine during voluntary exercise markedly decreases tissue fat and stimulates apoptosis and cyclin B1 in UVB-treated skin of hairless p53-knockout mice. Carcinogenesis. 2010; 31 (4): 671-678. [PMID: 19926639]
- Yip KW, Shi W, Pintilie M, et al. Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer. Clin Cancer Res. 2006 Oct 1;12(19):5726-32.[PMID: 17020977] (Human, IHC-P)
- Shariat SF, Karakiewicz PI, Godoy G, et al. Survivin as a prognostic marker for urothelial carcinoma of the bladder: a multicenter external validation study. Clin Cancer Res. 2009 Nov 15;15(22):7012-9. [PMID: 19903782]
- Kim EY, Teh SJ, Yang J, et al. TNFR2-deficient memory CD8 T cells provide superior protection against tumor cell growth. J Immunol. 2009 Nov 15;183(10):6051-7. [PMID: 19841176]
- Eberhard Y, McDermott S, Wang X, et al. Chelation of intracellular iron with the anti-fungal agent ciclopirox olamine induces cell death in leukemia myeloma cells. Blood 2009:blood-2009-2003-209965. [pubmed: 19589922]
- Song KY, Jung CK, Park WS, et al. Expression of the Antiapoptosis Gene Survivin Predicts Poor Prognosis of Stage III Gastric Adenocarcinoma. Jpn J Clin Oncol 2009;39(5):290-296. [pubmed: 19336448]
- Guha M, Plescia J, Leav I, et al. Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing. Cancer Res 2009:0008-5472.CAN-0009-0584. [pubmed: 19470765]
- Adler M, Muller K, Rached E, et al. Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity. Carcinogenesis 2009;30(4):711-719 [pubmed: 19237604]
- Song KY, Jung CK, Park WS, et al. Expression of the Antiapoptosis Gene Survivin Predicts Poor Prognosis of Stage III Gastric Adenocarcinoma. 2009:hyp020. [pubmed: 19336448]
- Rothberg BEG, Bracken MB, Rimm DL. Tissue Biomarkers for Prognosis in Cutaneous Melanoma: A Systematic Review Meta-analysis. 2009:djp038. [pubmed: 19318635]
- Lu J, Tan M, Huang W-C, et al. Mitotic Deregulation by Survivin in ErbB2-Overexpressing Breast Cancer Cells Contributes to Taxol Resistance. Clin Cancer Res. 2009 Feb 15;15(4):1326-34. [pubmed: 19228734]
- Lee JH, Palaia T, Ragolia L. Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation. Am J Physiol Cell Physiol. 2009 Feb;296(2):C327-38. [pubmed: 19052261]
- Zhang L, Murray F, Zahno A, et al. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19532-7. Epub 2008 Nov 25.
- Jiang X, Zhou J, Yuen NK, et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res. 2008 Dec 1;14(23):7726-32.
- Dai Y, Liu M, Tang W, et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis. Clin Cancer Res. 2008 Dec 1;14(23):7701-10.
- Xu Y., Fang, F., Ludewig, G., et al. A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells. DNA Cell Biol. 2004 Sep;23(9):527-37.
- Thirunavukkarasu, M., Han, Z., Zhan, L., et al. Adeno-sh-beta-catenin abolishes ischemic preconditioning-mediated cardioprotection by downregulation of its target genes VEGF, Bcl-2, and survivin in ischemic rat myocardium. Antioxid Redox Signal. 2008 Aug;10(8):1475-84.
- Seo SI, Gera L, Zhau HE, et al. BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Clin Cancer Res. 2008 Oct 1;14(19):6198-206.
- Symes JC, Kurin M, Fleshner NE, et al. Fas-mediated killing of primary prostate cancer cells is increased by mitoxantrone and docetaxel. Mol Cancer Ther. 2008 Sep;7(9):3018-28.
- Schaue D, Comin-uix B, Ribas A, et al. T-cell responses to survivin in cancer patients undergoing radiation therapy. Clin Cancer Res. 2008 Aug 1;14(15):4883-90.
- Lee CW, Raskett CM, Prudovsky I, et al. Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res. 2008 Jul 1;68(13):5273-81.
- Engels K, Knauer SK, Loibl S, et al. NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res. 2008 Jul 1;68(13):5159-66.
- Niibe Y, Watanabe J, Tsunoda S, et al. Concomitant expression of HER2 and HIF-1alpha is a predictor of poor prognosis in uterine cervical carcinoma treated with concurrent chemoradiotherapy: prospective analysis (KGROG0501). Eur J Gynaecol Oncol. 2010;31(5):491-6. [PubMed PMID: 21061787]
- Hebb ALO, Moore CS, Bhan V, et al. Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination. Mult Scler. 2008 Jun;14(5):577-94.
- Xia F, Canovas PM, Guadagno TM, et al. A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol. 2008 Sep;28(17):5299-311. Epub 2008 Jun 30.
- Xia F, Lee CW, Altieri DC. Tumor cell dependence on Ran-GTP-directed mitosis. Cancer Res. 2008 Mar 15;68(6):1826-33.
- Borghouts, C., C. Kunz, et al. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Mol Cancer Res. 2008 Feb;6(2):267-81.
- Lechler P, Wu X, Bernhardt W, et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol. 2007 Nov;171(5):1483-98.
- Connell, C. M., R. Colnaghi, et al. Nuclear survivin has reduced stability and is not cytoprotective. J Biol Chem. 2008 Feb 8;283(6):3289-96. Epub 2007 Dec 5.
- Singh, R. P., et al. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res. 2008 Jan 1;14(1):300-8.
- Tyagi, A., et al. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3248-55.
- Ghosh, J. C., et al. Hsp60 regulation of tumor cell apoptosis. J Biol Chem. 2008 Feb 22;283(8):5188-94. Epub 2007 Dec 17.
- Gong, J., et al. Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. Endocrinology. 2007 Sep;148(9):4489-99. Epub 2007 Jun 21.
- Niedbala, W., et al. Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15478-83. Epub 2007 Sep 17.
- Kindt, N., A. Menzebach, et al. Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J. 2008 Feb;22(2):510-21. Epub 2007 Sep 5.
- Huang, et al. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J Cell Biol. 2007 May 7;177(3):413-24.
- Moiseeva, E.P., et al. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther. 2007 Nov;6(11):3071-9.
- Skoufias, D.A., et al. Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. J Cell Biol. 2007 Nov 19;179(4):671-85.
- Deep, G., et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42. Epub 2007 Mar 26.
- Caldas, H., et al. Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood. 2007 Feb 15;109(4):1479-89. Epub 2006 Oct 12.
- Hahn, Joo-Yong., et al. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J Biol Chem. 2006 Oct 13;281(41):30979-89. Epub 2006 Aug 18.
- Robles, Ana I., et al. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin Cancer Res. 2006 Nov 1;12(21):6547-56.
- Kang BH, Altieri DC. Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein. J Biol Chem. 2006 Aug 25;281(34):24721-7. Epub 2006 Jun 27.
- Mao, J.T., et al. Celecoxib decreases Ki-67 proliferative index in active smokers. Clin Cancer Res. 2006 Jan 1;12(1):314-20.
- Kim, E.Y., et al. TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo. J Immunol. 2006 Jan 15;176(2):1026-35.
- Pennati, M., et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.
- Hata, T., et al. Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells. Mol Cancer Ther. 2005 Oct;4(10):1585-94.
- Fukuda, S., Pelus, L.M. Survivin, a cancer target with an emerging role in normal adult tissues. Mol Cancer Ther. 2006 May;5(5):1087-98.
- Asanuma, H., et al. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res. 2005 Dec 1;65(23):11018-25.
- MacCallum, D., et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res. 2005 Jun 15;65(12):5399-407.
- Geddis, A., et al. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood. 2004 Aug 15;104(4):1017-24. Epub 2004 May 6.
- Ferrer, A., et al. Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes. Oncogene. 2004 Nov 25;23(55):8941-9.
- Scrittori, L., et al. A small C-terminal sequence of Aurora B is responsible for localization and function. Mol Biol Cell. 2005 Jan;16(1):292-305. Epub 2004 Oct 27.
- Lubet, R., et al. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Carcinogenesis. 2005 Mar;26(3):571-8. Epub 2004 Dec 9.
- Vischioni, B., et al. Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer. Ann Oncol. 2004 Nov;15(11):1654-60.
- Rudkowski, J., et al. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L793-800. Epub 2003 Dec 5.
- Gassman, R., et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004 Jul 19;166(2):179-91. Epub 2004 Jul 12.
- Johnson, V., et al. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci. 2004 Mar 15;117(Pt 8):1577-89.
- Schlette, E., et al. Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma. J Clin Oncol. 2004 May 1;22(9):1682-8.
- Martinez, A., et al. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol. 2004 Feb;164(2):501-10.
- Asanuma, K., et al. Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells. J Immunol. 2004 Mar 15;172(6):3922-9.
- Mallikarjuna, G., et al. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res. 2004 Sep 1;64(17):6349-56.
- Krysan, K., et al. Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. Cancer Res. 2004 Sep 15;64 (18):6359-62.
- Chen, J., et al. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Ther. 2004 Nov;11(11):740-7.
- Chakravarti, A., et al. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene. 2004 Sep 30;23(45):7494-506.
- Zha, H., et al. Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray. Lab Invest. 2004 Feb;84(2):235-44.
- Komuro Y, Watanabe T, Tsurita G, Muto T, Nagawa H. Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis. Mod Pathol. 2004 Feb;17(2):264.
- Fornaro, M., et al. Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J Biol Chem. 2003 Dec 12;278(50):50402-11. Epub 2003 Sep 30.
- Amin, H., et al. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene. 2004 Jul 15;23(32):5426-34.
- Liu, T., et al. Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene. 2004 Jan 8;23(1):39-48.
- Ramp, U., et al. Apoptosis induction in renal cell carcinoma by TRAIL and gamma-radiation is impaired by deficient caspase-9 cleavage. Br J Cancer. 2003 Jun 2;88(11):1800-7.
- Altura, R., et al. Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade. Br J Cancer. 2003 Nov 3;89(9):1743-9.
- Lo Muzio, L., et al. Survivin expression in oral squamous cell carcinoma. Br J Cancer. 2003 Dec 15;89(12):2244-8.
- Chen, Y., et al. Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. Oncogene. 2003 Aug 7;22(32):4964-72.
- Chen, J., et al. Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res. 2003 Nov 15;63(22):7891-9.
- Honda, R., et al. Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell. 2003 Aug;14(8):3325-41. Epub 2003 May 29.
- Neef, R., et al. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol. 2003 Sep 1;162(5):863-75. Epub 2003 Aug 25.
- Carvalho, A, et al. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. J Cell Sci. 2003 Jul 15;116(Pt 14):2987-98. Epub 2003 Jun 3.
- Faderl, S., et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia. Blood. 2003 Jul 15;102(2):630-7. Epub 2003 Mar 27.
- Krysan, K: COX-2-dependent stabilization of survivin in non-small cell lung cancer. FASEB J. 2004 Jan;18(1):206-8. Epub 2003 Nov 3.
- Kirkiles-Smith, N., et al. IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression. J Immunol. 2004 Feb 1;172(3):1391-6.
- Fortugno, P., et al. Regulation of survivin function by Hsp90. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13791-6. Epub 2003 Nov 12.
- Beltrami, E., et al. Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis. J Biol Chem. 2004 Jan 16;279(3):2077-84. Epub 2003 Oct 27.
- Blanc-Brude, O., et al. Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Clin Cancer Res. 2003 Jul;9(7):2683-92.
- Zhang, C., et al. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. Clin Cancer Res. 2002 May;8(5):1234-40.
- Hauf, S., et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.
- Zeitlin, S., et al. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol. 2001 Dec 24;155(7):1147-57. Epub 2001 Dec 24.
- Mahotka, C., et al. Differential subcellular localization of functionally divergent survivin splice variants. Cell Death Differ. 2002 Dec;9(12):1334-42.
- Miranda MB, Dyer KF, Grandis JR, Johnson DE. Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells. Leukemia. 2003 Feb;17(2):390-400.
- Grabowski, P., et al. Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma. Br J Cancer. 2003 Jan 13;88(1):115-9.
- Kennedy, S., et al. Prognostic importance of survivin in breast cancer. Br J Cancer. 2003 Apr 7;88(7):1077-83.
- Blanc-Brude OP, Yu J, Simosa H, et al. Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med. 2002 Sep;8(9):987-94. [PMID: 12172543]
- Zhu, L., et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. 2001 Nov 23;508(3):369-74.
- Qanungo, S., et al. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene. 2002 Jun 13;21(26):4149-57.
- O'Connor, D.S., et al. A p34(cdc2) survival checkpoint in cancer. Cancer Cell. 2002 Jul;2(1):43-54.
- Yu J, Leung WK, Ebert MP, et al. Increased expression of survivin in gastric cancer patients and in first degree relatives. Br J Cancer. 2002 Jul 1;87(1):91-7. [PMID: 12085263] (Human, IHC-P)
- Giodini A, Kallio MJ, Wall NR, et al. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res. 2002 May 1;62(9):2462-7. [PMID: 11980633] (Human, Blocking)
- Chakravarti A, Noll E, Black PM, et al. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol. 2002 Feb 15;20(4):1063-8. [PMID: 11844831] (Human, WB)
- Wheatley SP, Carvalho A, Vagnarelli P, et al. INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001 Jun 5;11(11):886-90. [PMID: 11516652] (Human, ICC/IF)
- Fortugno P, Wall NR, Giodini A, et al. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci. 2002 Feb 1;115(Pt 3):575-85. [PMID: 11861764] (Human, WB, IP, ICC/IF)
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Jump to: Conjugated Antibodies, Positive Controls, Antibody Packs, Antibody Pairs, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsConjugated Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Survivin Antibody [DyLight 488] | NB500-201G | Ca, Fe, Hu, Mu, Rt | ICC, IF, IHC-P, IP, WB | | (99) | | | | Survivin Antibody [DyLight 550] | NB500-201R | Ca, Fe, Hu, Mu, Rt | ICC, IF, IHC-P, IP, WB | | (99) | | | | Survivin Antibody [DyLight 650] | NB500-201C | Ca, Fe, Hu, Mu, Rt | ICC, IF, IHC-P, IP, WB | | (99) | | | | Survivin Antibody [Biotin] | NB500-201B | Ca, Fe, Hu, Mu, Rt | ICC, IF, IHC-P, IP, WB | (3) | (93) | | | | Survivin Antibody [HRP] | NB500-201H | Ca, Fe, Hu, Mu, Rt | ICC, IF, IHC-P, IP, WB | (3) | (93) | | |
Positive ControlsAntibody Packs (1)Antibody Pairs (1)Lysates (2)Peptides and ProteinsPrimary Antibodies (66)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Survivin Antibody (60.11) | NB500-205 | Hu, Mu, Rt | FACS, ICC, IF, IP, WB | (3) | (13) | | | | Survivin Antibody (60.11) - Astrocyte Marker | NB500-238 | Hu, Mu, Rt | ICC, IHC, IHC-P, WB | (4) | (11) | | | | Survivin Antibody (8E2) | NB500-644 | Hu, Rt | ICC, IF, IHC-P | (1) | (13) | | | | Survivin Antibody (32.1) | NB500-237 | Hu | IF, IHC, IHC-P, WB | (1) | (5) | | | | Survivin [p Thr34] Antibody | NB500-236 | Bv, Ca, Fe, Hu, Mk, Mu, Po | ICC, IF, WB | (1) | (3) | | | | ... and 61 more. See All » |
RNAi (4)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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