Survivin Antibody (60.11) 0.1 ml

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Western Blot: Survivin Antibody (60.11) [NB500-238] - Cells were transfected with the pCMV6-ENTRY control or pCMV6-ENTRY Survivin cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Survivin.
Immunocytochemistry/Immunofluorescence: Survivin Antibody (60.11) [NB500-238] - Detection of Survivin protein (Green) in Hela cells using NB500-238. Nuclei(Blue) were counterstained using Hoechst 33258.
Immunohistochemistry-Paraffin: Survivin Antibody (60.11) [NB500-238] - Staining of ovary cancer.
Western Blot: Survivin Antibody (60.11) [NB500-238] - Survivin detection in 30ug of HeLa whole cell extract using NB500-238 at 1ug/ml.
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Ordering Information: NB500-238

  • Catalog Number
    NB500-238
  • Displayed Format
    Unconjugated
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Survivin Antibody (60.11) Summary

Species Human, Mouse, Rat
Tested Applications WB, ELISA, FLOW, ICC/IF, IHC, IHC-P
Clonality
Monoclonal
Host
Mouse
Gene
BIRC5
Purity
Protein G purified
Specificity
NB500-238 is specific for the cytoplasmic form of Survivin.
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Survivin Antibody (60.11) Details

Clone
60.11
Isotype
IgG2a Kappa
Epitope
The epitope recognized is between amino acids 27-67
Immunogen
Full length recombinant human Survivin [UniProt# O15392]
Localization
Cytoplasmic

Species Reactivity

Human, rat and mouse.
Reviewed Species Read 1 rated 4
using NB500-238 in the following species:

Publications Read Publications using NB500-238 in the following species:


Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
This Survivin (60.11) antibody is useful for Immunocytochemistry (PMID: 21976248) /Immunofluorescence, Immunohistochemistry on paraffin-embedded sections and Western blot. By WB, this antibody recognizes a band at ~16.5 kDa representing Survivin. Flow Cytometry and ELISA were reported in scientific literature.
Molecular Weight
16.5 kDa
Positive Controls
Other Available
Formats
7C Labeled NB500-238V2
Alexa Fluor (R) 405 Labeled NB500-238AF405
Alexa Fluor (R) 488 Labeled NB500-238AF488
Alexa Fluor (R) 647 Labeled NB500-238AF647
Alexa Fluor (R) 700 Labeled NB500-238AF700
Allophycocyanin Labeled NB500-238APC
Biotin Labeled NB500-238B
DyLight 350 Labeled NB500-238UV
DyLight 405 Labeled NB500-238V
DyLight 405LS Labeled NB500-238V3
DyLight 488 Labeled NB500-238G
DyLight 550 Labeled NB500-238R
DyLight 650 Labeled NB500-238C
DyLight 680 Labeled NB500-238FR
DyLight 755 Labeled NB500-238IR
FITC Labeled NB500-238F
HRP Labeled NB500-238H
PE Labeled NB500-238PE
PerCP Labeled NB500-238PCP
Reviewed Applications
Read 1 rated 4
using
NB500-238 in the following applications:

Publications
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NB500-238 in the following applications:

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Reviews

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Publications

Survivin Antibody (NB500-238) has been mentioned in at least 20 publications.
Earn rewards if you have published using Survivin Antibody (NB500-238).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Unit Size
0.1 ml
Concentration
0.9 mg/ml
Preservative
0.1% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol BIRC5
Entrez
Uniprot

Alternate Names for Survivin Antibody (60.11)

  • API4 survivin variant 3 alpha
  • Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
  • Apoptosis inhibitor survivin
  • baculoviral IAP repeat-containing 5
  • BIRC5
  • EPR-1
  • IAP4
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Related Products by Gene

Background

Survivin (BIRC5 or IAP4) is the smallest member of inhibitors of apoptosis proteins (X-linked IAP/XIAP, c-IAP1, c-IAP2, IAP-like protein-2/ ILP2, melanoma IAP/ ML-IAP, Livin, NAIP, and survivin) and besides its anti-apoptotic functions; survivin also regulates processes such as cell cycle, migration, metastasis etc. Highly critical in fetal development, survivin is generally no longer present in adult tissues; however, its re-expression occurs in cancers wherein it drives proliferation, metastasis, poor prognosis, and decreased patient survival. Survivin contains only one copy of a modified baculovirus IAP repeat (BIR, a domain required for caspases inactivation) which is used for homodimerization and for its interaction with other chromosome passenger proteins. Phosphorylation/mutation of Thr-48 in the BIR domain affects survivin's dual ability to inhibit apoptosis and regulate cell division. Under apoptotic stimuli involving mitochondria, survivin forms a complex with XIAP, thus increasing the stability of XIAP and its inhibitory activity against caspases. The survivin binding to mitochondrial Smac/DIABLO leads to a delayed Smac/DIABLO release in the cytoplasm resulting in prolonged cell survival. Survivin-HBXIP complex can bind to pro-caspase-9 for exerting prevention of mitochondrial apoptosis activation. For facilitating correct cell division, survivin recognize/complex with phospho-histone-H3 and associates with the chromosome passenger proteins (Aurora B, INCENP, and borealin) and this new complex is recruited to the mitotic centromers where it assists/ensure proper chromosomal segregation. Moreover, at the centrosomes of dividing cells, survivin binds to Cdk1 which is critical for cells to enter mitosis.

Reviews for Survivin Antibody (NB500-238) (1) 41

Read what people are saying who have used Survivin Antibody (NB500-238).

We have 1 review tested in 1 species: Mouse.
We have 1 review tested in 1: Western Blot.
Average Rating: 4
(Based on 1 reviews)

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Images Ratings Applications Species Reviewed By Date Details
  Very Good
WB Mouse Patrick Hsieh 12/08/2011
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Summary

ApplicationWestern Blot
Sample TestedMouse heart
Sample PretreatmentHeart lysate
SpeciesMouse

Blocking

Blocking DetailsBlocking Buffer: 5% BSA/TBST

Primary Anitbody

Dilution RatioPrimary Ab Dilution Ratio: 1:1000, Primary Ab Incubation Time: overnight

Details

Detection NotesDetection Method: ECL

Publications for Survivin Antibody (NB500-238) (20)

Read what people are writing who have used Survivin Antibody (NB500-238).

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 6 applications: WB, ELISA, FLOW, ICC/IF, IHC, IHC-P.

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WB
(8)
ELISA
(1)
FLOW
(1)
ICC/IF
(4)
IHC
(2)
IHC-P
(4)
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Human
(11)
Mouse
(4)
Rat
(1)
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Publication Applications Species
Zhu, L et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett508(3):369-74. 2001 Nov 23. [PMID: 11728454]
Xu, Z et al. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. J Biol Chem279(3):1838-44. 2004 Jan 16. [PMID: 14597622]
Ryan, B et al. Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer. Br J Cancer92(1):120-4. 2005 Jan 17. [PMID: 15611790]
Brocardo M et al. Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. J Biol Chem283(9):5950-9. 2008 Feb 29. [PMID: 18160396]
Lechler P, Schaumburger J, Kock FX et al. The Oncofetal Gene Survivin Promotes Cell Proliferation and Survival in Primary Human Osteoblastic Cells. Calcif Tissue Int. 2011 Jun 15. [PMID: 21674243] (ICC/IF, WB, Human) ICC/IF, WB Human
Femia AP, Salvianti F, Luceri C et al. Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis. Int J Cancer;131(3):529-36. 2012 Aug 1. [PMID: 21976248] (IHC-P, Rat) IHC-P Rat
Fortugno, P et al. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci115(Pt 3):575-85. 2002 Feb 1. [PMID: 11861764] (ELISA, WB, Human) ELISA, WB Human
Allen, S et al. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res63(3):567-72. 2003 Feb 1. [PMID: 12566297] (IHC-P, Mouse) IHC-P Mouse
Lechler P, Renkawitz T, Campean V et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer11(1):120. 2011 Apr 2. [PMID: 21457573] ( WB, IHC-P, ICC/IF, Human) ICC/IF, WB, IHC-P Human
Lechler P, Balakrishnan S, Schaumburger J et al. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord. 2011 Jul 5. [PMID: 21729321] (ICC/IF, Human) ICC/IF Human
Sakao K, Desineni S, Hahm ER, Singh SV. Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo. Prostate. 2011 Dec 7. [PMID: 22161756] (WB, IHC, Human, Mouse) IHC, WB Human, Mouse
Ku JH, Kwak C, Lee HS, Park HK, Lee E, Lee SE. Expression of survivin, a novel inhibitor of apoptosis, in superficial transitional cell carcinoma of the bladder. J Urol171(2 Pt 1):631-5. 2004 Feb. [PMID: 14713775]
Koyama S. Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma. Dig Dis Sci48(12):2290-300. 2003 Dec. [PMID: 14714615] (FLOW, Human) FLOW Human
Lechler P, Wu X, Bernhardt W et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol171(5):1483-98. 2007 Nov. [PMID: 17982126] (WB, IHC-P, Human, Mouse) WB, IHC-P Human, Mouse
Schoneberger H, Weiss A, Brill B et al. The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency. Hormone Molecular Biology and Clinical Investigation 135(1):1-9. 2011 Jun.
Lopergolo A, Tavecchio M, Lisanti S et al. Chk2 Phosphorylation of Survivin-{Delta}Ex3 Contributes to a DNA Damage-Sensing Checkpoint in Cancer Cancer Res 2012 Jul 1 [PMID: 22586065] (IHC, Human) IHC Human
Zhang H, Wang Y, Liu C et al. DNA and adenovirus tumor vaccine expressing truncated survivin generates specific immune responses and anti-tumor effects in a murine melanoma model Cancer Immunol Immunother 2012 Jun 17 [PMID: 22706381] (WB, Human) WB Human
Keerthivasan G, Liu H, Gump JM et al. A novel role for survivin in erythroblast enucleation Haematologica 2012 Oct [PMID: 22491741] (WB, ICC/IF, Mouse) ICC/IF, WB Mouse
Khan S, Jutzy JM, Valenzuela MM et al. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer PLoS One 2012 [PMID: 23091600] (WB, Human) WB Human
Rho JH, Lampe PD. High-Throughput Screening for Native Autoantigen-Autoantibody Complexes Using Antibody Microarrays J Proteome Res 2013 Mar 29 [PMID: 23541305] (Human) Human

Product General Protocols

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Video Protocols

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FAQs for Survivin (2)

  1. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  2. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

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Bioinformatics Tool for Survivin

Discover related pathways, diseases and genes to Survivin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Blogs on Survivin

Check out the latest blog posts on Survivin.
Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...  Read full blog post.

Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...  Read full blog post.

Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...  Read full blog post.

Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury....  Read full blog post.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.

Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...  Read full blog post.

PCNA Antibodies: Marking Cell Proliferation & DNA Replication
Proliferating Cell Nuclear Antigen (PCNA), also known as the polymerase delta auxiliary protein, is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It has a large role in cell cycle regulation and ...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

Survivin Sandwich ELISA: There's a Kit for That
The Survivin antibody is widely used in apoptosis studies, and as a cellular marker. Today, biochemists have a wide range of Survivin antibody products to choose from, suitable for use in Western Blot, Chromatin Immunoprecipitation (ChIP), Immunofluor...  Read full blog post.

Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...  Read full blog post.