Survivin Antibody (60.11) 0.1 ml

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Western Blot: Survivin Antibody (60.11) [NB500-205] - Survivin detected in rat aorta smooth muscle cell lysate.
Immunocytochemistry/Immunofluorescence: Survivin Antibody (60.11) [NB500-205] - HeLa cells stained NB500-205 (Green) detected with DyLight Fluor 488 conjugated anti-mouse IgG secondary antibody.  Nuclei are counterstained with Hoechst 33258 (Blue).
Flow Cytometry: Survivin Antibody (60.11) [NB500-205] - Staining of NTERA-2 cells using NB500-205 at a 1:2000 dilution detected using Dylight-488 conjugated goat anti-mouse IgG secondary antibody.
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Ordering Information: NB500-205

  • Catalog Number
    NB500-205
  • Displayed Format
    Unconjugated
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Survivin Antibody (60.11) Summary

Species Human, Mouse, Rat
Tested Applications WB, FLOW, ICC/IF, IHC-Fr, IHC-P, IP
Clonality
Monoclonal
Host
Mouse
Gene
BIRC5
Purity
Ascites
Specificity
NB500-205 is specific for the cytoplasmic form of survivin.
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Survivin Antibody (60.11) Details

Clone
60.11
Isotype
IgG2a Kappa
Epitope
The epitope recognized is between amino acids 57-67.
Immunogen
Full length recombinant human Survivin [UniProt# O15392]

Species Reactivity

Human, mouse and rat
Publications Read Publications using NB500-205 in the following species:


Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry 1:200
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation 1:10-1:500
Application Notes
This Survivin (60.11) antibody is useful for Flow Cytometry, Immunocytochemistry/Immunofluorescence and Immunoprecipitation. Immunohistochemistry-Paraffin and Western Blot were reported in scientific literature. This antibody weakly detects Survivin in Western blot; for this application we suggest using NB500-235 instead. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 22841823)
Molecular Weight
16.5 kDa
Positive Controls
Publications
Read Publications using
NB500-205 in the following applications:

Contact Information

Product PDFs

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Reviews

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Publications

Survivin Antibody (NB500-205) has been mentioned in at least 16 publications.
Earn rewards if you have published using Survivin Antibody (NB500-205).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Unit Size
0.1 ml
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.
Preservative
0.05% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol BIRC5
Entrez
Uniprot

Alternate Names for Survivin Antibody (60.11)

  • API4 survivin variant 3 alpha
  • Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5
  • Apoptosis inhibitor survivin
  • baculoviral IAP repeat-containing 5
  • BIRC5
  • EPR-1
  • IAP4
Show More

Related Products by Gene

Background

Survivin (BIRC5 or IAP4) is the smallest member of inhibitors of apoptosis proteins (X-linked IAP/XIAP, c-IAP1, c-IAP2, IAP-like protein-2/ ILP2, melanoma IAP/ ML-IAP, Livin, NAIP, and survivin) and besides its anti-apoptotic functions; survivin also regulates processes such as cell cycle, migration, metastasis etc. Highly critical in fetal development, survivin is generally no longer present in adult tissues; however, its re-expression occurs in cancers wherein it drives proliferation, metastasis, poor prognosis, and decreased patient survival. Survivin contains only one copy of a modified baculovirus IAP repeat (BIR, a domain required for caspases inactivation) which is used for homodimerization and for its interaction with other chromosome passenger proteins. Phosphorylation/mutation of Thr-48 in the BIR domain affects survivin's dual ability to inhibit apoptosis and regulate cell division. Under apoptotic stimuli involving mitochondria, survivin forms a complex with XIAP, thus increasing the stability of XIAP and its inhibitory activity against caspases. The survivin binding to mitochondrial Smac/DIABLO leads to a delayed Smac/DIABLO release in the cytoplasm resulting in prolonged cell survival. Survivin-HBXIP complex can bind to pro-caspase-9 for exerting prevention of mitochondrial apoptosis activation. For facilitating correct cell division, survivin recognize/complex with phospho-histone-H3 and associates with the chromosome passenger proteins (Aurora B, INCENP, and borealin) and this new complex is recruited to the mitotic centromers where it assists/ensure proper chromosomal segregation. Moreover, at the centrosomes of dividing cells, survivin binds to Cdk1 which is critical for cells to enter mitosis.

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Publications for Survivin Antibody (NB500-205) (16)

Read what people are writing who have used Survivin Antibody (NB500-205).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: WB, ICC/IF, IHC-Fr, IHC-P.

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Filter By Application
WB
(4)
ICC/IF
(2)
IHC-Fr
(1)
IHC-P
(1)
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Human
(6)
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Publication Applications Species
Zhu, L et al. Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett. 2001 Nov 23508(3):369-74. [PMID: 11728454]
Xu, Z et al. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. J Biol Chem;279(3):1838-44. 2004 Jan 16. [PMID: 14597622]
Ryan, B et al. Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer. Br J Cancer;92(1):120-4. 2005 Jan 17. [PMID: 15611790]
Brocardo, M, Y Lei et al. Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. J Biol Chem;283(9):5950-9. 2008 Feb 29. [PMID: 18160396]
Levkau B, Schafers M, Wohlschlaeger J et al. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation. 117(12):1583-93. Epub 2008 Mar 10. Erratum in: Circulation. 2008 Jun 17;117(24):e497. Fischer, Jens. 2008 Mar 25. [PMID: 18332262] (WB, IHC-P, Human) WB, IHC-P Human
Huang H, Fletcher L, Beeharry N et al. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. Cancer Res;68(10):3724-32. 2008 May 15. [PMID: 18483255] (ICC/IF, Human) ICC/IF Human
Fortugno, P et al. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci;115(Pt 3):575-85. 2002 Feb 1. [PMID: 11861764]
Allen, S et al. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res;63(3):567-72. 2003 Feb 1. [PMID: 12566297]
Hino R, Uozaki H, Inoue Y et al. Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A. Cancer Res;68(5):1427-35. 2008 Mar 1. [PMID: 18316606] (WB, ICC/IF, Human) ICC/IF, WB Human
Lechler P, Balakrishnan S, Schaumburger J, Grassel S, Baier C, Grifka J, Straub RH, Renkawitz T. The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation in vitro. BMC Musculoskelet Disord;12:150. 2011 Jul 5. [PMID: 21729321]
Ku JH, Kwak C, Lee HS, Park HK, Lee E, Lee SE. Expression of survivin, a novel inhibitor of apoptosis, in superficial transitional cell carcinoma of the bladder. J Urol;171(2 Pt 1):631-5. 2004 Feb. [PMID: 14713775]
Koyama S. Differential expression of intracellular apoptotic signaling molecules in tumor and tumor-infiltrating lymphocytes during development of invasion and/or metastasis of gastric carcinoma. Dig Dis Sci;48(12):2290-300. 2003 Dec. [PMID: 14714615]
Ansell, S et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. Leukemia;18(3):616-23. 2004 Mar. [PMID: 14749704] (WB, Human) WB Human
de Souza HS, West GA, Rebert N et al. Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease Gastroenterology 2012 Jun 26 [PMID: 22749932] (Human) Human
Knauer SK, Heinrich UR, Bier C et al. An otoprotective role for the apoptosis inhibitor protein survivin. Cell Death Dis 2010 Jul 1 [PMID: 21364656]
Hoel AW, Yu P, Nguyen KP, et al. Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo Am J Pathol. 2012 Oct [PMID: 22841823] (WB, IHC-Fr, Human) WB, IHC-Fr Human

Product General Protocols

View specific protocols for Survivin Antibody (NB500-205): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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FAQs for Survivin (2)

  1. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  2. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

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Bioinformatics Tool for Survivin

Discover related pathways, diseases and genes to Survivin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Blogs on Survivin

Check out the latest blog posts on Survivin.
Survivin is thrivin'
The survivin anti-apoptotic protein is the smallest member of a large family of proteins such as X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates basic physiological events such as the cell cycle, tumor...  Read full blog post.

Livin: On a Prayer
Livin is a member of the inhibitor of apoptosis proteins (IAP) family that regulates programmed cell death. The Livin protein contains a single baculovirus IAP repeat (BIR) essential for function, along with a COOH-terminal RING-type zinc finger domai...  Read full blog post.

Survivin: As long as I know how to live I know I will
Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, feta...  Read full blog post.

Survivin: Infographic
Survivin is involved in promoting cell proliferation and is an inhibitor of apoptosis. Survivin has a critical role in cancer proliferation and neural development. It may have an impact on neural cell proliferative responses following brain injury....  Read full blog post.

TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its ...  Read full blog post.

Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...  Read full blog post.

PCNA Antibodies: Marking Cell Proliferation & DNA Replication
Proliferating Cell Nuclear Antigen (PCNA), also known as the polymerase delta auxiliary protein, is a nuclear protein essential for DNA replication as well as DNA excision and mismatch repair pathways. It has a large role in cell cycle regulation and ...  Read full blog post.

TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...  Read full blog post.

Survivin Sandwich ELISA: There's a Kit for That
The Survivin antibody is widely used in apoptosis studies, and as a cellular marker. Today, biochemists have a wide range of Survivin antibody products to choose from, suitable for use in Western Blot, Chromatin Immunoprecipitation (ChIP), Immunofluor...  Read full blog post.

Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...  Read full blog post.