SREBP1 Antibody (NB100-2215)
SREBP1 Antibody
|
This product is fully covered under the Novus guarantee+ Policy.
Click
here for details.
|
|
Distributor Data...
|
|
anti-Class D basic helix-loop-helix protein 1 antibody, anti-SREBP 1c antibody, anti-BHLHD1 antibody, anti-Sterol regulatory element-binding transcription factor antibody, anti-Sterol regulatory element binding transcription factor 1 antibody, anti-Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1 antibody, anti-Sterol regulatory element binding protein 1 antibody, anti-SREBP 1 antibody, anti-SREBF1 antibody, anti-SREBF 1 antibody, anti-SRBP1 antibody, anti-D630008H06 antibody, anti-ADD 1 antibody, |
|
|
SREBP1 Antibody Summary: | | Gene: | SREBF1 |
|---|
| Purity: | Affinity purified |
|---|
| Host: | Rabbit |
|---|
| | Specificity: | This is specific for SREBP1. |
|---|
| Publications: | Antibody has been mentioned in at least 1 Publication. |
|---|
| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional SREBP1 Products SREBP1 Antibody Details: | Immunogen: | A synthetic peptide made to a portion of the human SREBP1 protein sequence (between residues 300-400). |
|---|
| Localization: | Integral membrane protein that moves from ER to Golgi in absence of sterols. |
|---|
Reacts with Human, Mouse, Rat and Porcine. 94% sequence identity with goat, bovine, and sheep protein. |
Notes: Unprocessed SREBP1 is an ~122 kDa integral membrane protein that moves from ER to golgi for processing. The first cleavage is performed by S2P at residue 490, and the resulting active portion is then translocated out of the golgi. This is the ~65 kDa mature form that is detected by NB100-2215. The second cleavage is performed by S1P at residue 530, and the resulting C-term portion (from residues 530-1147) remains in the golgi where it is detected as a ~65 kDa protein by NB100-60545. Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
|---|
| Buffer: | Tris-glycine and 150mM NaCl |
|---|
| Preservative: | 0.05% Sodium Azide |
|---|
| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
|---|
Background: SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes.
|
Images (1) Reviews (0) Related Products (36) Exploring SREBP1 Working with SREBP1
|
Jump to: Publications, Images, Protocols/Procedures, Ask a Question
|
Working with SREBP1
SREBP1 Antibody Images (1) Detection of SREBP1 using NB100-2215 (Lot C).
Lane 1: human liver
Lane 2: mouse liver |
|
|
|
Publications (1)
|
|
|
Ask a Scientist
Can't find an answer to your question about SREBP1? Ask us by using live
chat or by submitting your questions below:
|
Jump to: Conjugated Antibodies, Positive Controls, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
|
Related ProductsConjugated Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
|---|
| SREBP1 Antibody [DyLight 550] | NB100-2215R | Mu, Po, Rt | WB | | (1) | | | | SREBP1 Antibody [DyLight 488] | NB100-2215G | Mu, Po, Rt | WB | | | | | | SREBP1 Antibody [HRP] | NB100-2215H | Mu, Po, Rt | WB | | | | | | SREBP1 Antibody [DyLight 650] | NB100-2215C | Mu, Po, Rt | WB | | | | | | SREBP1 Antibody [Biotin] | NB100-2215B | Mu, Po, Rt | WB | | | | |
Positive ControlsPeptides and ProteinsPrimary Antibodies (19)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
|---|
| SREBP1 Antibody (2A4) | NB600-582 | Hu, Mu, Rt, SyHa | WB | (1) | (8) | | | | SREBP1 Antibody | NB100-60545 | Bv, Ha, Hu, Mu, Po, Rt | WB | (1) | | | | | SREBP1 Antibody (4B10) | H00006720-M01 | Hu | ELISA, WB | (3) | | | | | SREBP1 Antibody (4C11) | H00006720-M02 | Hu | ELISA, WB | (2) | | | | | SREBP1 Antibody (4G4) | H00006720-M03 | Hu | ELISA, WB | (2) | | | | | ... and 14 more. See All » |
RNAi (2)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
|---|
| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
|
|
