SR-BI/SR-BII Antibody (NB400-134)

SR-BI/SR-BII Antibody (NB400-134) (0.025 ml)

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	Catalog Number	NB400-134
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anti-CD36 antigen antibody, anti-Collagen type I receptor, thrombospondin receptor-like 1 antibody, anti-scavenger receptor class B type III antibody, anti-CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 antibody, anti-CD36L1scavenger receptor class B type 1 antibody, anti-SRB1scavenger receptor class B member 1 antibody, anti-SR-BIMGC138242 antibody, anti-CLA-1HDLQTL6 antibody, anti-CLA1CD36 antigen-like 1 antibody, anti-CD36 and LIMPII analogous 1 antibody, anti-scavenger receptor class B, member 1 antibody

SR-BI/SR-BII Antibody Summary:

Species:	Mu	Gene:	SCARB1
Applications:	WB, ICC, IF, IHC	Purity:	Whole antisera
Clonality:	Polyclonal	Host:	Rabbit
Specificity:	400-134 is specific for SR-BI and SR-BII.
Publications:	NB400-134 has been mentioned in at least 3 Publications

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Primary Antibodies
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SR-BI/SR-BII Antibody Details:

Immunogen:	A peptide from the extracellular domain (residues 230-380) of Scavenger Receptor-BI/BII that was expressed as two tandem copies in bacteria using the pET system.
Localization:	Lysosome; lysosomal membrane; multi-pass membrane protein.

Species Reactivity:

Reacts with mouse. Previous lots have been shown to react with rat and human Scavenger Receptors BI and Scavenger Receptors BII, as well.

Applications:

Uses:	In Western blot experiments a band of ~ 82 kDa is seen in tissues that express SR-BI and/or SR-BII such as liver, ovary, adrenal glands, and to as lesser extent testes, heart and mammary glands. Preliminary blocking experiments have worked with 1:100 dilutions, completely blocking the activity of ScarB1. Additional details are not available at this time. This antibody is also useful for immunocytochemistry/immunofluorescence.
Dilutions:	Immunocytochemistry 1:50-1:200, Immunofluorescence 1:1000, Immunohistochemistry, Western Blot 1:1000
Unit Size:	0.025 ml (also available: 0.1 ml)
Concentration:	This product is unpurified. Concentration is not relevant.

Packaging:

Storage:	Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Preservative:	0.02% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: SCARB1

Entrez:	20778 (Mouse)
Uniprot:	Q61009, O35114

Related Genes:

Background:

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

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