SR-BI Antibody Summary:

Species:	Mu
Applications:	ICC, IF, WB
Clonality:	Polyclonal

Gene:	SCARB1
Purity:	Affinity purified
Host:	Goat

Specificity:	This is specific for SR-BI protein.
Publications:	Antibody has been mentioned in at least 4 Publications.

Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.

View Additional SR-BI Products

Antibody Packs	Lysates
Peptides and Proteins	Primary Antibodies
RNAi

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SR-BI Antibody Details:

Immunogen:	A synthetic peptide made to the C-terminal region of murine SR-BI (between residues 400-509).
Localization:	Cell Membrane; multi-pass membrane protein

Species Reactivity:

Reacts with mouse, mink, rat and hamster. Customers have also reported positive detection in cytosolic fractions from 13-lined ground squirrel liver samples, with an unidentified non-specific band at ~60 kDa.

Applications:

Uses:	In Western blot a band of ~ 82 kDa is seen, representing SR-BI.
Dilutions:	immunofluorescence 1:10, Western Blot 1:500, Immunocytochemistry 1:50
Unit Size:	0.1 ml (also available: 0.025 ml (sample size))
Concentration:	3.0 mg/ml
Positive Controls:	2 Positive Controls
Conjugated Antibodies:	5 Conjugated Antibodies

Notes:

Licensed to Novus Biologicals LLC under U.S. Patent No 6,350,859.

Packaging:

Storage:	Store at 4 °C. Do not freeze.
Buffer:	Tris-citrate/phosphate [pH 7-8]
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: SCARB1

	20778 (Mouse)
	25073 (Rat)
	Q61009 (Mouse)
	P97943 (Rat)

Background:

High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.

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Working with SR-BI

SR-BI Antibody Images (1)

Detection of SR-BI in mouse liver lysate (20 ug) using NB 400-131 (2 ug/ml). ECL detection was 5 seconds.

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Publications (4)

SR-BI Antibody Product Specific:

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Protocols

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Jump to: Conjugated Antibodies, Positive Controls, Antibody Packs, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

Related Products

Conjugated Antibodies

Name	Catalog#	Reactivity	Applications
SR-BI Antibody [DyLight 488]	NB400-131G	Mu	ICC, IF, WB
SR-BI Antibody [DyLight 550]	NB400-131R	Mu	ICC, IF, WB
SR-BI Antibody [DyLight 650]	NB400-131C	Mu	ICC, IF, WB
SR-BI Antibody [HRP]	NB400-131H	Mu	ICC, IF, WB
SR-BI Antibody [Biotin]	NB400-131B	Mu	ICC, IF, WB

Positive Controls

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
Whole Normal Liver Lysate	NB820-59662	Mu	IP, WB
Other Positive Controls Mouse liver lysate.

Antibody Packs (1)

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
SR-BI Antibody Pack 3 vials	NB100-908	Hu, Mu, Rt	IF, IP, WB	(6)	(26)

Lysates (1)

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
SR-BI Lysate	NBL1-15720		WB	(1)

Peptides and Proteins

Name	Catalog#	Reactivity	Applications	Images
SR-BI Peptide	NB400-101PEP
SR-BI Peptide	NB400-131PEP
SR-BI Recombinant Protein	H00000949-P01	Hu	ELISA, WB	(1)

Primary Antibodies (14)

Name	Catalog#	Reactivity	Applications	Images	Publications
SR-BI Antibody	NB400-104	Hu, Mu, Rt	FACS, ICC, IF, IHC-P, IP, WB	(5)	(60)
SR-BI Antibody	NB400-101	Mu	FACS, ICC, IF, IHC, IP, WB	(2)	(59)
SR-BI Antibody	NB400-113	Hu, Mu	B/N, ICC, IF, IP	(2)	(5)
SR-BI Antibody (EP1556Y)	NB110-57591	Hu, Mu, Rt	ICC, IHC-P, WB	(1)	(3)
SR-BI Antibody	NBP1-77038	Hu, Mu, Rt	ELISA, IHC-P, WB	(2)
... and 9 more. See All »

RNAi (1)

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
SR-BI RNAi	H00000949-R01	Hu		(1)	(4)

Secondary Antibodies

Name	Catalog#	Reactivity	Applications	Publications
Goat IgG Antibody [FITC]	NB710-F	Gt	ICC, IHC-P
Goat IgG Antibody [Biotin]	NB710-B	Gt	ELISA, ICC, IHC-P, WB
Goat IgG Antibody [Alkaline Phosphatase]	NB710-AP	Gt	ELISA, ICC, IHC-P, WB
Goat IgG Antibody [HRP]	NB710-H	Gt	ELISA, ICC, IHC-P, WB	(4)
Goat IgG Antibody [Cy3]	NB120-6949	Gt	ELISA, FACS, ICC, IF, IHC-Fr, IHC-P
See All »

Jump to: Novus Explorer, Research Areas, In the News

SR-BI in Context

Research Areas related to SR-BI (5):

SR-BI in the News (1):

12/14/2009 SR-B1 is a doorway for Malaria

Novus Explorer for SR-BI gene

Try our bioinformatic tool that shows the relationships between SCARB1 and other genes, diseases, pathways and post-translational modifications.

SR-BI Antibody (NB400-131)

SR-BI Antibody