SR-BI Antibody (NB400-113)
SR-BI Antibody
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anti-SCARB1 antibody, anti-CD36 AND LIMPII ANALOGOUS 1 antibody, member 1 antibody, anti-thrombospondin receptor-like 1 antibody, anti-Thrombospondin receptor like 1 antibody, anti-SR-BI antibody, anti-SRBI antibody, anti-SR-B1 antibody, anti-SRB1 antibody, anti-SR BI antibody, anti-Scavenger Receptor-BI antibody, anti-Scavenger Receptor-B1 antibody, anti-scavenger receptor class B type III antibody, anti-Scavenger Receptor Class B Type 1 antibody, anti-scavenger receptor class B, anti-Scavebger Receptor Class B Member 1 antibody, anti-SCARB1 antibody, anti-MGC138242 antibody, anti-HCLA 1 antibody, anti-Collagen type I receptor antibody, anti-Collagen type I receptor, anti-CLA1 antibody, anti-CLA 1 antibody, anti-CD36L1 antibody, anti-CD36 Antigen like 1 antibody, anti-CD36 antigen antibody, anti-CD36 and LIMPII analogous 1 antibody, |
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SR-BI Antibody Summary: | | Gene: | SCARB1 |
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| Purity: | Whole antisera |
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| Host: | Rabbit |
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| | Specificity: | NB400-113 is specific for SR-BI. |
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| Publications: | Antibody has been mentioned in at least 5 Publications. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional SR-BI Products SR-BI Antibody Details: | Immunogen: | Adenovirus encoding mSR-BI. |
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NB 400-113 reacts with mouse SR-BI. It can block human SR-BI/Cla-1 (tested in HepG2 cells). |
| Uses: | NB 400-113 may be used for immunoprecipitation and for blocking the binding of ligands to SR-BI. This lot has not been used for Flow Cytometry, however previous lots have been used. This antibody does not work well for western analysis. We recommend NB 400-101, NB 400-104 or NB 400-131 for Western Blot analysis. |
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| Dilutions: | Blocking/Neutralizing 1:500-1000, Immunocytochemistry 1:50 - 1:200, Immunofluorescence 1:50 - 1:200, Immunoprecipitation 1:100 |
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| Unit Size: | 0.1 ml (also available: 0.025 ml (sample size)) |
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| Concentration: | This product is unpurified. Concentration is not relevant. |
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Notes: Licensed to Novus Biologicals LLC under U.S. Patent No 6,350,859. Packaging: | Storage: | Aliquot and store at -20 °C or -80 °C. Avoid freeze-thaw cycles. |
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| Preservative: | 0.05% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
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Images (2) Reviews (0) Related Products (22) Exploring SR-BI Working with SR-BI
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Jump to: Publications, Images, Protocols/Procedures, Ask a Question
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Working with SR-BI
SR-BI Antibody Images (2) Immunocytochemistry/Immunofluorescence: SR-BI Antibody [NB400-113] - Detection of SR-BI (Green) in Hela cells using NB400-113 at a 1:50 Dilution. Nuclei (Blue) were counterstained using Hoechst 33258. |  Western Blot: SR-BI Antibody [NB400-113] - Westerm blot detection of SR-BI (80kDa) in mouse testis lysate total protein using NB400-113. |
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Publications (5)SR-BI Antibody Product Specific:- Schäfer G, Guler R, Murray G, et al. The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. PLoS One. 2009 Dec 24;4(12). [PMID: 20041149]
- Song X, Fischer P, Chen X, et al.An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI. Int J Biol Sci. 2009 Oct 9;5(7):637-46. [PMID: 19847320]
more... - Gantman A, Fuhrman B, Aviram M, Hayek T. High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx. Biochem Biophys Res Commun. 2010 Jan 1;391(1):523-8. [PMID: 19941833]
- Kim HJ, Moradi H, Yuan J, et al. Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1297-306. Epub 2009 Apr 8.
- Francone, O.L., et al. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1198-205. Epub 2005 Apr 14.
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Jump to: Antibody Packs, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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Related ProductsAntibody Packs (1)Lysates (1)Peptides and ProteinsPrimary Antibodies (16)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| SR-BI Antibody | NB400-104 | Hu, Mu, Rt | FACS, ICC, IF, IHC-P, IP, WB | (5) | (60) | | | | SR-BI Antibody | NB400-101 | Mu | FACS, ICC, IF, IHC, IP, WB | (2) | (59) | | | | SR-BI Antibody | NB400-131 | Mu | ICC, IF, WB | (1) | (4) | | | | SR-BI Antibody (EP1556Y) | NB110-57591 | Hu, Mu, Rt | ICC, IHC-P, WB | (1) | (3) | | | | SR-BI Antibody | NBP1-77038 | Hu, Mu, Rt | ELISA, IHC-P, WB | (2) | | | | | ... and 11 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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