SR-BI Antibody (NB400-104H)
SR-BI Antibody [HRP]
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anti-CD36 AND LIMPII ANALOGOUS 1 antibody, anti-Thrombospondin receptor like 1 antibody, anti-SR-BI antibody, anti-SRBI antibody, anti-SR-B1 antibody, anti-SRB1 antibody, anti-SR BI antibody, anti-Scavenger Receptor-BI antibody, anti-Scavenger Receptor-B1 antibody, anti-Scavenger Receptor Class B Type 1 antibody, anti-Scavebger Receptor Class B Member 1 antibody, anti-SCARB1 antibody, anti-MGC138242 antibody, anti-Collagen type I receptor antibody, anti-CLA1 antibody, anti-CLA 1 antibody, anti-CD36L1 antibody, anti-CD36 Antigen like 1 antibody, anti-CD36 and LIMPII analogous 1 antibody, |
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SR-BI Antibody [HRP] Summary: | | Gene: | SCARB1 |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | Specificity: | 400-104 is specific for the SR-BI. |
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| Publications: | Antibody has been mentioned in at least 41 Publications. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional SR-BI Products SR-BI Antibody [HRP] Details: | Conjugate: | HRP |
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| Immunogen: | A C-terminal peptide containing residues from mouse Scavenger Receptor-BI (within residues 450-509). |
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Reacts with mouse, rat, and mink SR-BI and the long form of human CLA-I. |
| Uses: | In western blot experiments with NB 400-104 a band of ~ 82 kDa is seen in tissues that express SR-BI such as liver, ovary and adrenals and to as lesser extent testes, heart and mammary gland. A band is often also seen at ~57 kDa representing the unglycosylated form if SR-BI. Also works for immunohistochemistry and immunoprecipitation. |
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| Dilutions: | immunohistochemistry ,
immunoprecipitation ,
Western Blot 1:1000 -1:5000 |
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| Unit Size: | 0.1 ml |
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| Concentration: | 3.0 mg/ml |
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Notes: Licensed to Novus Biologicals LLC under U.S. Patent No 6,350,859. Packaging: | Storage: | Store at 4 °C. Do not freeze. |
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| Buffer: | PBS |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
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Images (4) Reviews (0) Related Products (22) Exploring SR-BI Working with SR-BI
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Jump to: Publications, Images, Ask a Question
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Working with SR-BI
SR-BI Antibody [HRP] Images (4) Immunolocalization of SR-BI in adult mink testis using NB400-104. SR-BI labeling is visible at the surface and along the outline of the large vacuole. Photo courtesy of R.M. Pelletier, University of Montreal. |  Detection of SR-BI in 25 ug of mouse liver lysate, using NB400-104 (lotJ) at a 1:1,000 dilution, shows distinct band at 82 kDa. |  FACS analysis of Huh7 and HepG2 cells using NB 400-104. Courtesy of Bruno Sainz, Jr., PhD, University of Illinois at Chicago. |  Staining of adrenal, cortex using NB400-104. |
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Publications (41)SR-BI Antibody [HRP] Product Specific:- Thomas-Moya, E., Gianotti, M., Proenza, A.M. Llado, I. (2006) The age-related paraoxonase 1 response is altered by long-term caloric restriction in male female rats, J. Lipid Res., 47, 2042-2048.
- Sane, A.T., Sinnett, D., Delvin, E., Bendayan, M., Marcil, V., Menard, D., Beaulieu, J.-F. Levy, E. (2006) Localization role of NPC1L1 in cholesterol absorption in human intestine, J. Lipid Res., 47, 2112-2120.
more... - Azhar, S., Medicherla, S., Shen, W.-J., Fujioka, Y., Fong, L.G., Reaven, E. Cooper, A.D. (2006) LDL cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells, J. Lipid Res., 47, 2538-2550.
- Akpovi, C.D., Yoon, S.R., Vitale, M.L. Pelletier, R.M. (2006) The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis, J. Lipid Res., 47, 2233-2247.
- Zhong, J., Gastaminza, P., Chung, J., Stamataki, Z., Isogawa, M., Cheng, G., McKeating, J. A., Chisari, F. V. (2006) Persistent Hepatitis C Virus Infection In Vitro: Coevolution of Virus Host, 80, 11082-11093.
- Zhang, C., Yin, W., Liao, D., Huang, L., Tang, C., Tsutsumi, K., Wang, Z., Liu, Y., Li, Q., Hou, H., Cai, M., Xiao, J. (2006) NO-1886 upregulates ATP binding cassette transporter A1 inhibits diet-induced atherosclerosis in Chinese Bama minipigs, 47, 2055-2063.
- Yesilaltay, A., Morales, M. G., Amigo, L., Zanlungo, S., Rigotti, A., Karackattu, S. L., Donahee, M. H., Kozarsky, K. F., Krieger, M. (2006) Effects of Hepatic Expression of the High-Density Lipoprotein Receptor SR-BI on Lipoprotein Metabolism Female Fertility, 147, 1577-1588.
- Wadsack, C., Tabano, S., Maier, A., Hiden, U., Alvino, G., Cozzi, V., Huttinger, M., Schneider, W. J., Lang, U., Cetin, I., Desoye, G. (2007) Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors maternal lipoprotein composition, 292, E476-484.
- Timmers, C., Sharma, N., Opavsky, R., Maiti, B., Wu, L., Wu, J., Orringer, D., Trikha, P., Saavedra, H. I., Leone, G. (2007) E2f1, E2f2, E2f3 Control E2F Target Expression Cellular Proliferation via a p53-Dependent Negative Feedback Loop, 27, 65-78.
- Timmers, C., Sharma, N., Opavsky, R., Maiti, B., Wu, L., Wu, J., Orringer, D., Trikha, P., Saavedra, H. I., Leone, G. (2006) E2f1-3 Control E2F-target Expression Cellular Proliferation via a p53-dependent Negative Feedback Loop, MCB.02147-02105.
- Thomas-Moya, E., Gianotti, M., Proenza, A. M., Llado, I. (2006) The age-related paraoxonase 1 response is altered by long-term caloric restriction in male female rats, 47, 2042-2048.
- 3. Goti, D., et al. Effects of lipoprotein lipase on uptake transcytosis of low density lipoprotein (LDL) LDL-associated alpha-Tocopherol in a porcine in vitro blood-brain barrier model. JBC Papers in Press. Published on May 24, 2002 as Manuscript M203989200.
- 2. Witt, W., et al. Regulation by vitamin E of the scavenger receptor B1 in rat liver HepG2 cells. Journal of Lipid Research. 41: 2009-2016, 2000.
- 1. Hullinger, Thomas G., et al. PAK1 Inhibition of the Human SR-BI Promoter in Macrophages is Independent of the PAK1 Kinase Activity but Requires the GTPase Binding Domain. JBC Papers in Press.276(50): 46807-46814, 2001.
- Karpac J, Czyzewska KA, Kern A, et al. Failure of adrenal corticosterone production in pro-opiomelanocortin deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Am J Physiol Endocrinol Metab 2008:00762.02007.
- van der Velde AE, Vrins CLJ, van den Oever K, et al. Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol 2008;295(1):G203-208.
- Li L, Thompson PA, Kitchens RL. Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors. J Lipid Res. May 22, 2008:M800172-JLR200.
- Frank PG, Pavlides S, Cheung MWC, et al. Role of caveolin-1 in the regulation of lipoprotein metabolism. Am J Physiol Cell Physiol 2008;295(1):C242-248.
- Tancevski I, Wehinger A, Demetz E, et al. Reduced Plasma High-Density Lipoprotein Cholesterol in Hyperthyroid Mice Coincides with Decreased Hepatic Adenosine 5'-Triphosphate-Binding Cassette Transporter 1 Expression. Endocrinology 2008;149(7):3708-3712.
- During A, Doraiswamy S, Harrison EH. Xanthophylls are preferentially taken up compared to beta -carotene by retinal cells via a scavenger receptor BI-dependent mechanism. J Lipid Res. April 19, 2008:M700580-JLR200.
- Barth H, Schnober EK, Neumann-Haefelin C, et al. Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake Cross-Presentation by Human Dendritic Cells. J Virol. April 1, 2008;82(7):3466-79.
- Ashraf MZ, Kar NS, Chen X, et al. Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters. J Biol Chem. April 18, 2008;283(16):10408-14.
- Montoudis, A., Seidman, E., Boudreau, F., et al. Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation cholesterol uptake. J. Lipid Res. May 2008; 49: 961-972. (WB)
- Drover VA, Nguyen DV, Bastie CC, et al. CD36 Mediates Both Cellular Uptake of Very Long Chain Fatty Acids Their Intestinal Absorption in Mice. J Biol Chem. May 9, 2008;283(19):13108-15.
- Valiyaveettil, M., N. Kar, et al. (2008). Oxidized high-density lipoprotein inhibits platelet activation aggregation via scavenger receptor BI. Blood. 111: 1962-1971.
- Ashraf, M. Z., N. S. Kar, et al. (2008). Specific oxidized phospholipids inhibit scavenger receptor BI mediated selective uptake of cholesteryl esters. J. Biol. Chem.: M710474200.
- Tietge UJF, Nijstad N, Havinga R, et al. Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion. J Lipid Res. March 1, 2008;49(3):563-71.
- Barth H, Schnober EK, Neumann-Haefelin C, et al. Scavenger Receptor Class B is Required for Hepatitis C Virus Uptake Cross-presentation by Human Dendritic Cells. J Virol. 2008 January 23, 2008:JVI.02478-07.
- Yvan-Charvet L, Pagler TA, Wang N, et al. SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. J Lipid Res. 2008 January 1, 2008;49(1):107-14.
- Eacker SM, Agrawal N, Qian K, et al. Hormonal Regulation of Testicular Steroid Cholesterol Homeostasis. Mol Endocrinol. March 1, 2008;22(3):623-35.
- During A, Harrison EH. Mechanisms of provitamin A (carotenoid) vitamin A (retinol) transport into out of intestinal Caco-2 cells. J Lipid Res. 2007 October 1, 2007;48(10):2283-94. (Westen Blot)
- Atshaves BP, McIntosh AL, Payne HR, et al. SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes. J Lipid Res. 2007 October 1, 2007;48(10):2193-211. (Western Blot)
- Qu, Shen., et al. Effects of apoA-V VLDL metaobolism in APOC3 transgenic mice. Journal of Lipid Research. 2007.
- Thomas-Moya, E., et al. The age-related paraoxonase 1 response is altered by long-term caloric restriction in male female rats. J. Lipid Res. 47: 2042-2048, 2006.
- Harder, C.J., et al. Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. J. Lipid Res. 47:492-503, 2006.
- Akpovi, C.D., et al. Predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis. J. Lipid Res. Vol. 47, 2006, pp. 2233-2247.
- Johansson, L., et al. Selective thyroid receptor modulation by GC-1 reduces serum lipids stimulates steps of reverse cholesterol transport in euthyroid mice. PNAS. 102(29): 10297-10302, 2005. (Western blot, mouse)
- Brodeur, M.R. et al. Physiological importance of SR-B1 in the in vivo metabolsim of human HDL LDL in male female mice. J. of Lipid Res. 46:687-696, 2005. (Western Blot, Mouse)
- Lalanne, F., et al. Wild-type PCSK9 Inhibits LDL Clearance But Dose Not Affect ApoB Containing Lipoprotein Production in Mouse Cultured Cells. 2005.
- Lemieux, C., et al. The Hypolipidemic Action of the Selective Estrogen Receptor Modulator Acolbifene is Associated with Decreased Liver MTP Increased SR-B1 LDL Receptors. J. Lipid Res. 46:1285-1294, 2005. (Western blot, rat)
- Han, J., et al. Functional Interplay Between the Macrophage Scanvenger Receptor Class B Type I Pitavastatin (NK-104). Circulation. 110: 3472-3479, 2004.
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Related ProductsAntibody Packs (1)Lysates (1)Peptides and ProteinsPrimary Antibodies (14)| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| SR-BI Antibody | NB400-104 | Hu, Mu, Rt | FACS, ICC, IF, IHC-P, IP, WB | (5) | (60) | | | | SR-BI Antibody | NB400-101 | Mu | FACS, ICC, IF, IHC, IP, WB | (2) | (59) | | | | SR-BI Antibody | NB400-113 | Hu, Mu | B/N, ICC, IF, IP | (2) | (5) | | | | SR-BI Antibody | NB400-131 | Mu | ICC, IF, WB | (1) | (4) | | | | SR-BI Antibody (EP1556Y) | NB110-57591 | Hu, Mu, Rt | ICC, IHC-P, WB | (1) | (3) | | | | ... and 9 more. See All » |
RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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