SLC12A1 Antibody (NBP1-44269)
SLC12A1 Antibody
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Distributor Data...
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anti-BSC1 antibody, anti-NKCC2 antibody, anti-MGC48843 antibody, |
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SLC12A1 Antibody Summary: | | Gene: | SLC12A1 |
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| Purity: | IgG purified |
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| Host: | Rabbit |
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| | Specificity: | This antibody is specific to the ~160 kDa NKCC2 protein |
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| Publications: | Antibody has at least 1 Background Reference. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional SLC12A1 Products SLC12A1 Antibody Details: | Immunogen: | Produced against a synthetic peptide mapping to a segment (amino acids 33-55, NP_001073158) of the Nterminal tail of rat NKCC2 (antibody desgination L224). |
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This antibody is reactive in Rat, Mouse and Human |
| Uses: | This antibody is useful for Western Blot |
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| Dilutions: | Western Blot 1:1000 |
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| TMW: | 160 kDa |
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| Unit Size: | 0.1 mg |
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| Concentration: | Please see the vial label for concentration. |
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Packaging: | Storage: | Store at -20 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 50% glycerol |
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| Preservative: | No Preservative |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide (1).
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Working with SLC12A1
SLC12A1 Antibody Images (0)
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Publications (1)SLC12A1 Antibody Background References:- 2. Xue H., et al. (2009) Neurogastroentrol Motil. 21(10):1068-1089.
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