S-arrestin Antibody

The members of the G protein coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. Members of the beta-Arrestin family regulate receptor binding to G proteins. beta-Arrestins have been found to be located at postsynaptic sites, where they are thought to act in concert with betaARK (betaARK1, also designated GRK 2, or betaARK2, also designated GRK 3) to regulate G protein-coupled neurotransmitter receptors. Expression of beta-Arrestin-1 and beta-Arrestin-2 is seen predominantly in spleen and neuronal tissues. It has been shown that beta-Arrestin-1 expression is modulated by intracellular cAMP, which may be a novel mechanism for the regulation of receptor-mediated responses.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-92141

• S-arrestin Antibodies
• S-arrestin Lysate
• S-arrestin Protein