PPAR alpha Antibody (NB100-63215)
PPAR alpha Antibody
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Distributor Data...
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Anti-hPPAR antibody; Anti-MGC2237 antibody; Anti-MGC2452 antibody; Anti-NR1C1 antibody; Anti-Peroxisome proliferator activated receptor alpha antibody; Anti-PPAR antibody; Anti-PPARA antibody, |
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PPAR alpha Antibody Summary: | | Gene: | PPARA |
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| Purity: | Affinity purified |
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| Host: | Rabbit |
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| | Specificity: | NB100-63215 detects an epitope within the N-terminal region of human peroxisome proliferator-activated receptor, alpha (PPARA), a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes. |
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| Publications: | Antibody has at least 2 Background References. |
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| | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional PPAR alpha Products PPAR alpha Antibody Details: | Isotype: | IgG |
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| Immunogen: | Synthetic peptide corresponding to amino acids 1-18 of human PPAR alpha. |
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| Localization: | Cytoplasmic and Nuclear
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Human. Not yet tested in other species. |
| Uses: | This antibody is useful for ELISA, Western Blot |
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| Dilutions: | ELISA
Western Blot |
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| Unit Size: | 0.05 mg |
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| Concentration: | 1.0 mg/ml |
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Packaging: | Storage: | Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles. |
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| Buffer: | Phosphate buffered saline, pH7.2 |
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| Preservative: | 0.01% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Reviews (0) Related Products (23) Exploring PPAR alpha Working with PPAR alpha
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Jump to: Publications, Ask a Question
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Working with PPAR alpha
PPAR alpha Antibody Images (0)
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Publications (2)PPAR alpha Antibody Background References:- Lefebvre, P. et al. (2006) Sorting out the roles of PPAR alpha in energy metabolism vascular homeostasis. J. Clin. Invest. 116: 571-580.
- Haluzik, M.M. Haluzik, M. (2006) PPAR-alpha insulin sensitivity. Physiol. Res. 55: 115-122.
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Jump to: Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies
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