PMP22 Antibody (Hu1) 0.1 ml Schwann Cell Marker

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Immunohistochemistry: PMP22 Antibody (Hu1) [NB110-59086] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey.
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Ordering Information: NB110-59086

  • Catalog Number
    NB110-59086
  • Displayed Format
    Unconjugated
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PMP22 Antibody (Hu1) Summary

Species Human, Primate, Bovine (Negative), Mouse (Negative), Rat (Negative)
Tested Applications WB, IHC, IHC-P
Clonality
Monoclonal
Host
Mouse
Gene
PMP22
Purity
Protein G purified
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PMP22 Antibody (Hu1) Details

Clone
Hu1
Isotype
IgG1 Kappa
Marker
Schwann Cell Marker
Epitope
Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Immunogen
Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Localization
Membrane

Species Reactivity

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.
Publications Read Publications using NB110-59086 in the following species:


Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.
Positive Controls
Other Available
Formats
Alexa Fluor (R) 405 Labeled NB110-59086AF405
Alexa Fluor (R) 488 Labeled NB110-59086AF488
Alexa Fluor (R) 647 Labeled NB110-59086AF647
Alexa Fluor (R) 700 Labeled NB110-59086AF700
Biotin Labeled NB110-59086B
DyLight 405 Labeled NB110-59086V
DyLight 488 Labeled NB110-59086G
DyLight 550 Labeled NB110-59086R
DyLight 650 Labeled NB110-59086C
FITC Labeled NB110-59086F
HRP Labeled NB110-59086H
Publications
Read a Publication using
NB110-59086 in the following applications:

  • 1 publication
  • 1 publication

Contact Information

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Publications

PMP22 Antibody (NB110-59086) has been mentioned in at least 1 publication.
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Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Tris-glycine, 150 mM NaCl
Unit Size
0.1 ml
Concentration
0.9 mg/ml
Preservative
0.05% Sodium Azide
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

Gene Symbol PMP22
Entrez
Uniprot

Alternate Names for PMP22 Antibody (Hu1)

  • CMT1A
  • CMT1E
  • GAS3
  • GAS-3DSS
  • growth arrest-specific 3
  • Growth arrest-specific protein 3
  • HMSNIA
  • HNPP
  • MGC20769
  • peripheral myelin protein 22
  • PMP-22
  • Sp110
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Related Products by Gene

Background

PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.

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Publications for PMP22 Antibody (NB110-59086) (1)

Read what people are writing who have used PMP22 Antibody (NB110-59086).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: WB, IHC.

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Product General Protocols

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Video Protocols

WB Video Protocol

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FAQs for PMP22 (3)

  1. Does this antibody recognize ONLY human PMP22, or does it also recognize mouse PMP22? I am looking for something that will detect ONLY human cells, transplanted into a mouse brain.
    • We have confirmed that this antibody does not detect the mouse protein so this would be a good candidate for you. I would recommend using a directly conjugated primary antibody, as this will eliminate some of the background you may see by using an anti mouse secondary in mouse brain.
  2. In the immunohistochemistry paraffin section protocol....the PBS buffer....should it be at certain pH?
    • For IHC application, different labs cites the pH of PBS buffer in the range of 7.1 - 7.6 but most commonly used pH is pH 7.4 (this is what we use in our lab). You may use this PBS (pH 7.4) for making permeablization buffer, antibody diluent buffers and for making wash buffer. For more on the protocol that we use in our lab and for IHC-P troubleshooting suggestions, you may visit: IHC-P Protocol and IHC-P Troubleshooting.
  3. I was wondering what does Format 7C mean as far as anitbodies go?
    • 7C is a fluorophore - it is useful for FLOW. The details of the fluor are (A=425, E=500)

Bioinformatics Tool for PMP22

Discover related pathways, diseases and genes to PMP22. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Bioinformatics Tool

Blogs on PMP22

Check out the latest blog posts on PMP22.
PMP22 Antibodies Assist in PNS Myelin Repair Research
Novus Biologicals recently added a new  PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene....  Read full blog post.