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PMP22 Antibody (Hu1) 0.1ml Oligodendrocyte Marker

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Catalog Number  NB110-59086
Sample Size Available
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Jump to Information on PMP22 Antibody (NB110-59086)

PMP22 Antibody (Hu1) Summary
 
Species Human, Primate, Bovine (Negative), Mouse (Negative), Rat (Negative)
Tested Applications WB, IHC, IHC-P
Clonality Monoclonal
Host Mouse
Gene PMP22
Purity Protein G purified
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PMP22 Antibody (Hu1) Details
 
Clone Hu1
Isotype IgG1 Kappa
Marker Oligodendrocyte Marker
Epitope Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Immunogen Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Localization Membrane
Species Reactivity
 
Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.
Publications Read 1 using NB110-59086 in the following species:
 
Applications/Dilutions
 
Dilutions
  • Western Blot
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes

This PMP22 antibody is useful for Immunohistochemistry-Paraffin.
Positive Controls

1 Positive Control
Directly Conjugated
Formats
DyLight 550 Labeled NB110-59086R
Biotin Labeled NB110-59086B
DyLight 488 Labeled NB110-59086G
DyLight 650 Labeled NB110-59086C
HRP Labeled NB110-59086H
Learn about Custom Antibody Labeling
Publications
Read 1 publication using
NB110-59086 in the following applications:
  • WB2publications
Product PDFs
  Download PDF Datasheet
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Publications
PMP22 Antibody (NB110-59086) has been mentioned in at least 1 publication.
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Protocols and FAQs
Controls & Support Products
View all related PMP22 Controls and Support Products.
Research Tools
View all PMP22 Research Tools.
Packaging, Storage & Formulations
 
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer Tris-glycine, 150 mM NaCl
Unit Size 0.1ml (also available in 0.025ml (sample size))
Concentration 0.9 mg/ml
Preservative 0.05% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 6 months from date of receipt.
Bioinformatics
 
Gene Symbol PMP22
Entrez
Uniprot
Alternate Names for PMP22
 
  • GAS3
  • CMT1A
  • growth arrest-specific 3
  • PMP-22
  • Growth arrest-specific protein 3
  • MGC20769
  • Sp110
  • HMSNIA
  • HNPP
  • GAS-3DSS
  • CMT1E
  • peripheral myelin protein 22
Related Products by Gene
 
MPZ, GJB1, TNF, GDI1, MPO, MID1, IL6, RPLP0, EGR2, IL10, KIF1B, MAD2L1BP, MBP, TREMBLER, ACAD8, NOS2, MAG, PTGS2, COL2A1, IFNG
Background
 
PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.