PMP22 Antibody (Hu1) 0.1 ml Schwann Cell Marker

PMP22 NB110-59086

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Ordering Information: NB110-59086

Catalog NumberNB110-59086
  • FormUnconjugated
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PMP22 Antibody (Hu1) Summary

 
Species Human, Primate, Bovine (Negative), Mouse (Negative), Rat (Negative)
Tested Applications WB, IHC, IHC-P
Clonality Monoclonal
Host Mouse
Gene PMP22
Purity Protein G purified
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PMP22 Antibody (Hu1) Details

 
Clone Hu1
Isotype IgG1 Kappa
Marker Schwann Cell Marker
Epitope Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Immunogen Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Localization Membrane

Species Reactivity

 
Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.
Publications Read Publications using NB110-59086 in the following species:
 

Applications/Dilutions

 
Dilutions
  • Western Blot
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes

This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.

Positive Controls

1 Positive Control

Other Available
Formats
Alexa Fluor (R) 405 Labeled NB110-59086AF405
Alexa Fluor (R) 488 Labeled NB110-59086AF488
Alexa Fluor (R) 647 Labeled NB110-59086AF647
Alexa Fluor (R) 700 Labeled NB110-59086AF700
Biotin Labeled NB110-59086B
DyLight 405 Labeled NB110-59086V
DyLight 488 Labeled NB110-59086G
DyLight 550 Labeled NB110-59086R
DyLight 650 Labeled NB110-59086C
FITC Labeled NB110-59086F
HRP Labeled NB110-59086H
Learn about Custom Antibody Labeling
Publications
Read publication using
NB110-59086 in the following applications:
  • WB1publications
  • IHC1publications

Product PDFs

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Publications

PMP22 Antibody (NB110-59086) has been mentioned in at least 1 publication.
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Protocols and FAQs

Controls & Support Products

Research Tools

View all PMP22 Research Tools.

Packaging, Storage & Formulations

 
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer Tris-glycine, 150 mM NaCl
Unit Size 0.1 ml (also available in 0.025 ml (sample size))
Concentration 0.9 mg/ml
Preservative 0.05% Sodium Azide
Limitations This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

 
Gene Symbol PMP22
Entrez
Uniprot

Alternate Names for PMP22

 
  • GAS3
  • CMT1A
  • growth arrest-specific 3
  • PMP-22
  • Growth arrest-specific protein 3
  • MGC20769
  • Sp110
  • HMSNIA
  • HNPP
  • GAS-3DSS
  • CMT1E
  • peripheral myelin protein 22

Related Products by Gene

Background

 
PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.