PI 3 Kinase catalytic subunit gamma Antibody (NB110-57349)
PI 3 Kinase catalytic subunit gamma Antibody (Y388)
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anti-PI3Kgamma antibody, anti-PI3 kinase p110 subunit gamma antibody, anti-Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit gamma isoform antibody, |
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PI 3 Kinase catalytic subunit gamma Antibody (Y388) Summary: | | Gene: | PIK3CG |
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| Purity: | IgG purified |
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| Host: | Rabbit |
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| | | Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur. |
View Additional PI 3 Kinase catalytic subunit gamma Products PI 3 Kinase catalytic subunit gamma Antibody (Y388) Details: | Clone: | Y388 |
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| Isotype: | IgG |
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| Immunogen: | A synthetic peptide of in the N-term of human PI3-K p110 gamma was used as an immunogen. |
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Reacts in Human. Does not react to Mouse or Rat. |
| Uses: | This product is useful for: Western Blot, Immunoprecipitation, Flow Cytometry. In Western blot this antibody detects a band at approximately 110kDa. |
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| Dilutions: | Western Blot 1:1000, Immunoprecipitation 1:50, Flow Cytometry 1:50 |
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| TMW: | 110 kDa |
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| Unit Size: | 0.1 ml |
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| Concentration: | Please see the vial label for concentration. |
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| Positive Controls: | 1 Positive Controls |
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Packaging: | Storage: | Store at -20 °C. Avoid freeze-thaw cycles. |
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| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
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| Preservative: | 0.01% Sodium Azide |
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| Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. |
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Background: PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit (3). The gamma isoform is most clostly related to p110 alpha, and beta and has been shown not to interact with p85 in vivo (4). It has been found that in p110-gamma protein expression is lost in primary colorectal adeno-carcinomas and in colon cancer cell lines (5)
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Images (1) Reviews (0) Related Products (12) Exploring PI 3 Kinase catalytic subunit gamma Working with PI 3 Kinase catalytic subunit gamma
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Jump to: Publications, Images, Ask a Question
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Working with PI 3 Kinase catalytic subunit gamma
PI 3 Kinase catalytic subunit gamma Antibody (Y388) Images (1) Western Blot: P13-Kinase p110 subunit gamma Antibody (Y388) [NB110-57349] - Western blot analysis on Jurkat cell lysate using anti-PI3-kinase p110 subunit gamma (N-term) (cat. # 110-57349), dilution 1:1,000 |
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Publications (4)PI 3 Kinase catalytic subunit gamma Antibody (Y388) Background References:- Stoyanov et al. Science 269: 690-693, 19955. Sasaki et al. Nature 406: 897-902, 2000.
- Hu, P., Mondino, A., Skolnik, E. Y., Schlessinger, J. (1993) Mol. Cell. Biol. 13, 7677-7688
more... - Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dh, R., Panayatou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtnidge, S. A., Parker, P. J., Waterfield, M. D. (1991) Cell 70, 419-429
- Otsu, M., Hiles, I. D., Gout, I., Fry, M. J., Ruiz-Larrea, F., Panayatou, G., Thompson, A., Dh, R., Hsuan, J., Totty, N., Smith, A. D., Morgan, S. J., Courtnidge, S. A., Parker, P. J., Waterfield, M. D. (1992) Cell 65, 91-104
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Related ProductsPositive ControlsAntibody Pairs (1)Lysates (1)Primary Antibodies (3)RNAi (1)Secondary Antibodies| Name | Catalog# | Reactivity | Applications | Images | Publications | Reviews | |
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| Rabbit IgG Antibody [HRP] | NB730-H | Rb | ELISA, ICC, IHC-P, WB | | (5) | | | | Rabbit IgG Antibody [FITC] | NB730-F | Rb | ICC, IHC-P | | (1) | | | | Rabbit IgG Antibody [Biotin] | NB730-B | Rb | ELISA, ICC, IHC-P, WB | | | | | | Rabbit IgG, H/L Chains Antibody [DyLight 488] | NBP1-72944 | Rb | FLISA, IF, WB | (3) | | | | | Rabbit IgG Antibody [Alkaline Phosphatase] | NB730-AP | Rb | ELISA, ICC, IHC-P, WB | | (1) | | | | See All » |
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