PARP Antibody (5A5) (NB120-18376)

PARP Antibody (5A5) (NB120-18376) (0.1 mg)

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	Catalog Number	NB120-18376
	Size(s)	0.1 mg	Price:
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anti-NAD(+) ADP-ribosyltransferase 1 antibody, anti-EC 2.4.2 antibody, anti-ADPRT 1 antibody, anti-poly(ADP-ribose) synthetase antibody, anti-PARP-1 antibody, anti-poly(ADP-ribose) polymerase antibody, anti-Poly[ADP-ribose] synthase 1 antibody, anti-poly(ADP-ribosyl)transferase antibody, anti-poly (ADP-ribose) polymerase family, member 1 antibody, anti-poly [ADP-ribose] polymerase 1 antibody, anti-ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) antibody, anti-PPOLpADPRT-1 antibody, anti-ADPRTADP-ribosyltransferase NAD(+) antibody, anti-PARPADPRT1 antibody, anti-EC 2.4.2.30 antibody, anti-poly (ADP-ribose) polymerase 1 antibody

PARP Antibody (5A5) Summary:

Species:	Hu, Mu	Gene:	PARP1
Applications:	WB, IF	Purity:	Protein G purified
Clonality:	Monoclonal	Host:	Mouse
Specificity:	PARP (5A5)
Publications:	NB120-18376 has been mentioned in at least 1 Publication

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Peptides and Proteins	Primary Antibodies
RNAi
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PARP Antibody (5A5) Details:

Clone:	5A5
Isotype:	IgG1 Kappa
Immunogen:	Recombinant fragment (Human).
Localization:	Nuclear

Species Reactivity:

Cross-reacts with Human and Mouse.

Applications:

Uses:	Immunofluorescence, Western Blot Detects a band of approximately 113 kDa.
Dilutions:	immunofluorescence , Western Blot 1 ug/ml
Unit Size:	0.1 mg
Concentration:	0.5 mg/ml
Positive Controls:	1 Positive Controls
Conjugated Antibodies:	1 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C. Do not freeze.
Buffer:	PBS. pH 7.2
Preservative:	0.09% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: PARP1

Entrez:	142 (Human)
Entrez:	11545 (Mouse)

Related Genes:

Background:

PARP (Poly (ADP-ribose) polymerase) is a 113 kD nuclear protein that can exist as a homo- or hetero-dimer. This protein acts as a molecular "nick sensor" and functions in base excision repair, poly(ADP-ribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2 and is a target for caspase cleavage during apoptosis. PARP interacts with proteins in the base excision repair complex containing at least XRCC1, PARP2, POLB and LIG3. In addition PARP forms heterodimers with PARP2, and interacts with PARP3.

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PARP Antibody (5A5) Images (1)

	Western Blot: H: PARP Antibody (5A5) [NB120-18376] - la cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with monoclonal anti-PARP antibody. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence system

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Publications (1)

PARP Antibody (5A5) Product Specific:

Fu Y, Chang A, Chang L, et al. Differential Regulation of Transforming Growth Factor {beta} Signaling Pathways by Notch in Human Endothelial Cells. J Biol Chem 2009;284(29):19452-19462. [pubmed: 19473993]

Protocols

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Jump to: Conjugated Antibodies, Positive Controls, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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Conjugated Antibodies

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
PARP Antibody (5A5) [Biotin]	NB100-78366	Hu, Mu	IF, WB	(4)	(4)

Positive Controls

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
Hela Whole Cell Lysate	NB800-PC1		WB	(2)

Peptides and Proteins

Name	Catalog#	Reactivity	Applications	Images
PARP Protein	NBP1-37088	Hu	ELISA, PAGE	(1)
PARP Partial Recombinant Protein	H00000142-Q01	Hu	ELISA, WB	(1)
PARP Protein	P3547	Hu	PAGE
PARP Protein	NBP1-99635	Hu

Primary Antibodies (18)

Name	Catalog#	Reactivity	Applications	Images	Publications
PARP Antibody (C-2-10)	NB100-111	Bv, Ch(-), Ha, Hu, Mk, Mu, Rt	ELISA, ICC, WB	(1)	(3)
PARP Antibody (A6.4.12)	NB100-64828	Dr, Hu, Mu, Rt, Xp	ELISA, IF, IHC-Fr, IHC-P, IP, WB	(1)	(3)
PARP Antibody (E102)	NB110-57323	Hu, Mu, Rt	FACS, ICC, IHC-P, WB	(4)	(1)
PARP Antibody	NB100-61616	Hu	IHC-P, WB	(3)
PARP Antibody	NSB698	Bv, Hu	ICC, WB	(2)	(2)
... and 13 more. See All »

RNAi (1)

Name	Catalog#	Reactivity	Applications	Images	Publications	Reviews
PARP RNAi	H00000142-R01	Hu		(1)	(4)

Secondary Antibodies

Name	Catalog#	Reactivity	Applications	Publications
Mouse IgG Antibody [Biotin]	NB720-B	Mu	ELISA, IHC-P, WB
Mouse IgG Antibody [HRP]	NB720-H	Mu	ELISA, ICC, IHC-P, WB
Mouse IgG Antibody [Alkaline Phosphatase]	NB720-AP	Mu	ELISA, ICC, IHC-P, WB	(1)
Mouse IgG Antibody [FITC]	NB720-F	Mu	ICC, IHC-P	(2)
Mouse IgG Antibody	NB120-7056	Bv(-), Ch(-), Eq(-), Gp(-), Gt(-), Ha(-), Hu(-), Mu, Rb(-), Rt(-), Sh(-)	ELISA, IHC-P, IP, WB
See All »